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... albumin-to-creatinine ratio (UACR) is used to diagnose and stage chronic kidney disease (CKD), a worldwide public health concern with high associated morbidity and mortality. ...- 2018-10-17 11:40
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x-chromosome chronic kidney disease genetic X-chromosome and kidney function: Evidence ... analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by ...- 2023-04-03 15:12
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... cardiovascular disorder associated with high mortality and morbidity, affecting approximately 40 million people ... ventricular impairment results in reduced exercise capacity and fluid congestion3. Limited understanding of the causal ... loci, which included established loci for coronary heart disease, dilated cardiomyopathy, and atrial fibrillation. We ...- 2018-11-28 14:09
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... genome-wide association (GWA) studies of lifespan and longevity is apolipoprotein E (ApoE). Genome-wide ... to date, in which we applied a rigorous definition of cases and controls based on country-, gender-, and birth ... correlated with father’s age at death, coronary artery disease and diabetes-related phenotypes, which gives some ...- 2018-09-19 15:40
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... serum urate levels correlate with cardio-metabolic traits and can cause gout. Understanding mechanisms that control serum urate levels may help to develop novel gout therapies and provide insights into correlations between serum urate ...- 2018-12-11 16:57 - 1 comment
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... 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and UK Biobank to identify genetic loci for rapid eGFRcrea ... 2 /year (“Rapid3”; 34,874 cases, 107,090 controls) and (ii) incident eGFRcrea <60 mL/min/1.73m 2 accompanied by ...- 2020-05-19 14:55
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... : Vitamin D insufficiency is common, correctable and influenced by genetic factors. This would be of public health importance if vitamin D was causal in the risk of disease. We sought to identify low-frequency genetic ...- 2016-12-14 15:44 - 1 comment
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... PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, atrial fibrillation and cardiovascular mortality1,2. We conducted a ... variation at many genes underlying monogenic forms of heart disease. Genetically determined PR interval prolongation is ...- 2019-03-28 15:17
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... glomerular filtration rate (eGFR) measures kidney function and eGFR decline can lead to kidney failure, necessitating ... these or other loci to eGFR decline remain largely unknown and approaches to longitudinal GWAS underexplored. We ... a first catalogue of genetics for kidney function decline and CKD progression, key to identify individuals at-risk and ...- 2021-05-20 12:31
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UMOD is a major risk gene for monogenic and complex forms of kidney disease. The encoded protein uromodulin is highly abundant in urine and related to kidney stones, hypertension, and pathogen ...- 2021-07-08 11:15