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... formed by the non-enzymatic glycation of proteins, lipids, and nucleic acids.1 A common consequence of the formation of ... serum cystatin C, eGFR based on cystatin C, self-reported health status, glucose, diabetes, LDL, HDL, C-reactive ...- 2013-03-12 14:08
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... (SCDs) in the general population. Objective: To develop and validate a SCD risk score. Design, Setting, and ... 45-64y; 55% female; 73% white; 5% prevalent coronary heart disease (CHD)] was used for the risk score development. Prospective Cardiovascular Health Study (CHS) cohort [n=5,061; age > 65y; 57% female, ...- 2015-07-16 15:58 - 4 comments
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colorectal cancer statins Medication Background and Rationale Colorectal cancer (CRC) is one of the most ... CRC by even a small amount would yield a substantial public health benefit. 3-hydroxy-3-methylglutaryl coenzyme A ... of medication use that may accompany declining health (such as before a diagnosis of CRC). To address this ...- 2013-03-12 14:39
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... well-recognized risk factor for type 2 diabetes among young and middle-aged adults, but the relationship between body composition and type 2 diabetes is not well described among older ... and women 65 years of age and older in the Cardiovascular Health Study. Measures of adiposity were derived from ...- 2013-03-12 14:39
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Importance: High throughput genotyping and sequencing across the genome may identify secondary ... genetic findings with evidence of association with disease risk or treatment response. The population prevalence and clinical significance of secondary findings is largely ...- 2017-05-10 12:43
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... aortic diameter is a consequence of the ageing process and is considered the main determinant of Abdominal Aortic Aneurysm (AAA). We aimed to investigate the genetic and clinical determinants of abdominal aortic diameter ... been implicated in the genetics of other vascular diseases. Abdominal Aortic Aneurysm (AAA) GWAS meta-analysis ...- 2019-06-12 14:51
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Handgrip is a widely used measure of muscle strength and a predictor of a range of morbidities including cardiovascular diseases and all-cause mortality. We aimed to identify new ...- 2020-04-21 16:07
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... are risk factors for cardiovascular morbidity and mortality. Medical knowledge of electrolyte associations ... cardiac electrophysiology is based only on in-vitro models and diseased populations. Objectives: To investigate ...- 2018-09-11 15:26
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... Apolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-ε4 ... Study, Long Life Family Study, Cardiovascular Health Study, Health-ABC Study). Setting and participants: ... to other ethnicities, and multiple measurements of serum lipids could better capture their effect on survival. ...- 2017-09-08 15:03
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... progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their ... , DCDC5 , NRIP1 , SLC22A2 ), one DM-specific ( CSRNP1 ) and one noDM-specific ( MED1/NEUROD2 ). By accounting for ... 4 additional with differences ( SH3BP4 , ALPL , LOXL4 and PIK3CG ) and CUBN. CUBN is the prime locus for ...- 2021-11-08 16:44