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... outcomes, we are building a population-level simulation model, MICROSIM, based on prior CV[ 1 ]and dementia[ 2 ]models incorporating data and estimates from a variety of population-level data sources, published risk models and meta-analyses of controlled trials. The ...- 2021-09-17 07:53 - 5 comments
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... dementia are needed. Observational studies have shown that modifiable vascular risk factors (VRFs) are associated with ... to design trials optimally. 4 We created a microsimulation model for cognitive decline, dementia, recurrent stroke, and ... virtual trials to compare two treatment arms (a hemoglobin A1c [HbA1c] target of 7.0 to 8.0% vs. <7.0 %). The ...- 2024-12-06 06:35 - 2 comments
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... are incompletely understood. Vascular risk factors are modifiable and influence AD/ ADRD risk , and likely ... severity, treatment, glycemic control as measured by hemoglobin A1c, high blood pressure, cardiovascular disease, and ... from Aim 1 will be incorporated into the Aim 3 simulation modeling . Aim 1 (CHS contributes data): Quantify the ...- 2021-09-15 06:42 - 7 comments
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... VRFs contribute to cognitive decline and AD/ADRD and are modifiable. 3 Yet, incomplete understanding of how VRFs ... estimated difficulty. We will compute factor scores from models for each domain using the regression-based method in ... cognitive outcome, we will build a linear mixed-effects model using the pooled data from the cohorts. 9 When ...- 2021-06-29 09:09 - 4 comments
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... States cohort studies (1971-2021). Linear mixed-effects models estimated changes in cognition after incident stroke. ... was associated with a faster decline in global cognition in models without and with adjustment for cumulative mean ... is unknown whether lowering BP, glucose (glycosylated hemoglobin <7%), and cholesterol (low-density lipoprotein<70 ...- 2019-08-27 13:44 - 11 comments
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... evaluate the mechanisms behind these changes to identify modifiable targets. heart failure cognition pooled cohort ... function will be assessed using linear mixed effects models adjusted for years since baseline. Two sequential, linear mixed-effects models will be used to estimate the effect of HF on ...- 2022-10-21 09:14 - 8 comments
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... critical to understand the extent to which depression is a modifiable risk factor that could reduce sex/gender and ... difficulty 25,26 . We have computed factor scores from models for each domain using the regression-based method in ... IV. Brief analysis plan and methods Linear mixed-effects models will measure changes in each continuous cognitive ...- 2023-07-24 19:57 - 5 comments
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... Northern Manhattan Study (1971-2019). Linear mixed-effects models estimated the associations between incident MI and ... -0.20, -0.08)).There was a suggestion that race and sex modified the degree of change in the decline in global ... with one MI event, and that the rate of change will be modified by race (worse for blacks) and sex (worse for ...- 2020-09-10 13:46 - 7 comments
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... Alzheimer’s disease and ADRDs, and these risk factors are modifiable. Vascular risk factor interventions are likely to ... to its estimated difficulty. We computed factor scores from models for each domain using the regression-based method in ... Sum test or χ2 test as appropriate. Linear mixed-effects models will measure changes in each continuous cognitive ...- 2019-11-25 08:36 - 10 comments
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... as appropriate. We will use Cox proportional regression models and the pooled cohort data to test the association ... before and after adjusting for other covariates. The basic model is: hazard of first ischemic stroke (t) = h 0 (t) exp(b 1 sex + b 2 age + g other covariates). The basic model will be adjusted for a set of covariates including ...- 2024-05-23 07:21 - 4 comments