... dysfunction is a core component of the aging process and may play a key role in atherosclerotic cardiovascular disease (CVD). mtDNA copy number (mtDNA-CN), which ... from three prospective cohort studies—Cardiovascular Health Study (CHS), Atherosclerosis Risk in Communities ...
mitochondria 1. Introduction [Rationale and background]:Energy has been hypothesized to be central to health in later life (Ruggiero C, Ferrucci L, 2006)however ... many of the clinical problems observed in age-related diseaseand frailty, including movement disorders and muscle ...