... for nicotine dependence in European Americans (MAF=0.35), and contributes to risk in African Americans (MAF=0.06). To ... risk. These newly identified variants may have important health implications by influencing risk for smoking-related diseases and response to cessation therapies. Genetics ...
... with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that such ... to investigate the inbreeding effects on traits of public health importance by measuring the overall length of ... whereas many important risk factors for late-onset complex diseases have not. inbreeding depression Genetics CHARGE ...