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... variants in 1393 persons with late-onset Alzheimer’s disease (LOAD) and 8141 cognitively intact controls from four population-based cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ...- 2014-08-15 12:49
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... the most significant genetic risk factor for of Alzheimer disease (AD) and may mask effects of other loci. Methods We re-analyzed ... Project (IGAP) Consortium in APOE ε4+ (10,246 cases and 11,924 controls) and APOE ε4- (7,231 cases and 19,603 ...- 2014-08-08 12:01
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... to coordinate movement, memory, motivation, reinforcement and learning. To investigate how common genetic variants ... studies (GWAS) of the volumes of seven subcortical regions and intracranial volume, derived from magnetic resonance ... in intracerebral hemorrhage (ch1q22), Huntington’s disease (chr2p21), neuro-inflammation (chr2p21), ...- 2014-06-05 11:36
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... Histidine is a semi-essential amino acid with anti-oxidant and anti-inflammatory properties. Few data are available on ... the associations between genetic variants, histidine levels and incident coronary heart disease (CHD) in a population-based sample. Methods and ...- 2014-04-15 09:42
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... pressure (BP) is a major risk factor for cardiovascular disease. More than 60 loci in the genome have been ... previously; most are non-coding, have small effects on BP, and even in aggregate they explain only a small proportion ... variation in BP, we conducted discovery association and meta-analyses of single variant-based and gene-based ...- 2014-12-16 11:34
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... trait with significant intra-individual variability and is susceptible to measurement error. Genetic studies of BP generally use single-visit measurements and, thus, are not able to correct for variability that ... but measured across time would improve phenotypic accuracy, and thereby increase statistical power to detect genetic ...- 2014-01-13 14:12
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... represent important indicators of cognitive dysfunction and dementia. (1) We plan to search for genetic associations ... from the CHS Cognition Study, with adjustment for sex, age, and study clinic. Brief analysis plan and methods: This is a ... against manually derived data in patients with HIV disease (7). To assess global atrophy of the hippocampus, ...- 2014-01-07 14:39
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... to coordinate movement, memory, motivation, reinforcement and learning. To investigate how common genetic variants ... studies (GWAS) of the volumes of seven subcortical regions and intracranial volume, derived from magnetic resonance ... influencing the volumes of the putamen, caudate nucleus, and intracranial volume, and found stronger evidence for two ...- 2014-04-21 17:29
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... study we aimed to investigate the association between CETP and HDL in humans in more detail by a meta-analysis of ... identify independent variants associated to HDL-C. Methods and results: Our meta-analysis of 64,095 individuals imputed ... segregation of this variant.The association between HDL-C and CETP has been described previously by Teslovich et al. ...- 2014-11-25 16:11