... an endogenous inhibitor 25-hydroxyvitamin-D-1α-hydroxylase and decreases 1,25(OH) 2 D production. Thus, higher ... hospitalizations of 8.6 years. Setting: The Cardiovascular Health Study conducted in four U.S. communities. ... associations differed by the presence of chronic kidney disease (CKD) (eGFR CysC <60 ml/min/1.73m 2 [n=832] or urine ...