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... is associated with adverse outcomes in chronic kidney disease (CKD) and in-patients with acute medical conditions. Little is ... 5132 individuals aged ≥ 65 years in the Cardiovascular Health Study (CHS), we investigated associations between ...- 2014-03-13 20:01 - 2 comments
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... common with ageing, strongly prognostic for end-stage renal disease (ESRD), but poorly captured by eGFR or urine ACR ... type III collagen in the process of fibrosis deposition, and released into urine. Higher urine PIIINP ... in spot urine specimens from the 1996-97 Cardiovascular Health Study visit among individuals who had CKD progression ...- 2014-03-10 10:10
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biomarkers 1. Introduction [Rationale and background]: Background: In CHS, we began to look at methods to combine markers of aging and age-related disease and developed the concept of a subclinical, ... emphasizing the need to measure multiple systems to define healthy aging. In total, these observations suggest that ...- 2014-03-15 12:58 - 4 comments
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... uncertainty whether the associations of chronic kidney disease (CKD) with mortality and end-stage renal disease (ESRD) differ between men and women. Objective: To assess the presence of a gender ...- 2014-03-13 14:40
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... of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high sensitivity troponin T (TnT) are associated with ... participants free of heart failure in the Cardiovascular Health Study. NT-proBNP and TnT were measured from baseline ... never), prevalent CVD (MI, CAGB, PCI, stroke), diabetes, lipids, eGFR level, troponin T. We will also examine the ...- 2014-03-26 16:48
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Background: Decline in serum androgens is common among older men and has been associated with cardiovascular disease, but the role of androgen levels in risk of AF has ... coronary or cerebrovascular disease in the Cardiovascular Health Study. Among 1019 men without prevalent AF followed ...- 2014-03-19 07:51 - 5 comments
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Associations between a physiologic index of comorbidity, putative biomarkers of aging, and mortality
... we began to look at methods to combine markers of aging and age-related disease and developed the concept of a subclinical, ... emphasizing the need to measure multiple systems to define healthy aging. In total, these observations suggest that ...- 2014-03-07 14:42 - 3 comments -
... between thyroid function tests within the euthyroid range and adverse outcomes in older adults. Methods: Men and women aged 65 and older enrolled in the Cardiovascular Health Study whose thyrotropin (TSH), free thyroxine (FT4), ... 1 hip fracture, 2 , 3 dementia, 4 coronary heart disease, 5 lipids, 6 blood pressure, 7 BMI, 8 , 9 and mortality. 10 ...- 2014-03-20 17:08 - 1 comment
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... risk factors 1. Introduction [Rationale and background]:Venous thromboembolism (VTE) is a substantial public health concern. Data from the United States shows that ... arterial thromboembolism (ATE), comprising coronary heart disease, stroke or transient cerebral ischaemic attack, and ...- 2014-03-18 12:02 - 2 comments
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... at lower estimated glomerular filtration rate (eGFR) and higher albuminuria (albumin to creatinine ratio, ACR). The additional risk associated with age, sex, and race has not been quantified across the full range of ... in general population cohorts; 79,519 in chronic kidney disease cohorts) from 14 cohorts in 8 countries, we ...- 2014-03-12 10:43