Importance: Disease burden does not account fully for functional status, ... adaptation. Adaptive factors may be translatable to promote healthy aging. Objective: To ascertain if adapters ... 3 groups by extent of disease, assessed non-invasively, and vigor/frailty: expected agers (N=1458, extent of disease ...
... the degree to which older adult spouses’ frailty status and depressive symptoms are interrelated and (b) whether ... and wave 7 (1996–1997) of the Cardiovascular Health Study (CHS), a multi-site, longitudinal, ... observational study of risk factors for cardiovascular disease in adults 65 years or older. PARTICIPANTS: Each ...
... trajectories are not well established in elderly persons, and their association with death and cardiovascular disease is uncertain. Methods: We included data from ... 4,067 participants alive at year 7 of the Cardiovascular Health Study (CHS). We used hierarchical cluster analysis ...
Background: Recent evidence suggests that a healthy lifestyle among older adults can compress the period ... lifestyle factors could also influence hospital admission and stay among older adults during their last five years of life, after accounting for cumulative chronic disease burden. Methods: We examined data from 3780 ...
... uncertainty whether the associations of chronic kidney disease (CKD) with mortality and end-stage renal disease (ESRD) differ between men and women. Objective: To assess the presence of a gender ...
Background: Despite being frequently prescribed and their well-established cardio-protective benefits, the ... data from 4,952 participants enrolled in the Cardiovascular health study from 1989-99 to 1999/2000. We conceptualized ... attainment, alcohol intake, physical activity level; lipids: total cholesterol, HDL, LDL, triglycerides; ...
... adiponectin Sudden cardiac death Introduction [Rationale and background]: Sudden cardiac death (SCD) is a major cause ... cause of SCD. 27 Accordingly, population-based studies of healthy middle aged adults have linked higher adiponectin ... intake, body mass index (BMI), physical activity, serum lipids levels (total-cholesterol, LDL-cholesterol, ...
... the relationship between TSH, free thyroxine (FT4), and total T3 concentrations and adverse outcomes in older ... 65 years and over (n=360) enrolled in the Cardiovascular Health Study and taking levothyroxine. Main Outcome ... hip fracture, atrial fibrillation, dementia, coronary heart disease (CHD), heart failure, and all-cause death. Results: ...
... a drug target can mimic pharmacological action of a drug and can be used to infer the probable clinical efficacy of ... also tested the association of carrier status with plasma lipids. RESULTS: In the discovery study, we identified four ... sequencing in the discovery study, and the Women’s Health Initiative (WHI). 14 All participants underwent a ...
... compression of morbidity Introduction [Rationale and background]: There is surprisingly little data on end ... economic and policy implications.In the Cardiovascular Health Study, where 69% of participants have died by Year 18 ... socio-demographic factors, lifestyle factors and chronic disease status at baseline. A longer lifespan will be ...