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Importance: Chronic lower respiratory disease (CLRD), which includes chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, and asthma, is the third leading cause-of-death in the US. ... is the third leading cause of death and a major source of health care costs in the United States (US) ( 1 ). ...- 2014-12-24 06:58 - 9 comments
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... elucidate the practical limitations of methods to estimate randomized controlled trial effects from observational data. ... We used data from 5,294 participants in the Cardiovascular Health Study from 1989-2004. For non-cardiovascular ... death from CHD) Covariates: Cardiovascular risk variables : lipids (total cholesterol, HDL, LDL, triglycerides), ...- 2014-12-15 10:05 - 5 comments
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... between time-varying measures of physical function and survival in men and women aged 70 years and over, while accounting for the time-varying effects of health and lifestyle characteristics. Methods: 1,846 women ... strength are thought to capture the complexity of multiple diseases and to provide a global measure of health. 2 There ...- 2014-12-13 03:18 - 4 comments
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glycemia albuminuria retinopathy leukoaraiosis Microvascular disease Introduction [Rationale and background]: The screening tests for type 2 diabetes ... C, eGFR based on cystatin C, aspirin use, self-reported health status, CRP, prevalent CVD (CHD, stroke/TIA, PAD), ...- 2014-12-11 23:16 - 2 comments
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... the long-term course of psychiatric/physical conditions and other risk factors that are potentially related to time ... Due to the prospective nature of the Cardiovascular Health Study (CHS) and the fact that spouse pairs form a ... designated to identify the risk factors for cardiovascular disease in older adults [2]. It enrolled 5888 men and women ...- 2014-12-09 10:33 - 7 comments
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... may be an important next step for optimizing VTE prevention and treatment. “Lifetime risk” is an easily ... two large, prospective cohort studies: the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in ... the factor V Leiden (17.1%), or with sickle cell trait or disease (18.2%). Lifetime risk estimates differed by cohort; ...- 2014-12-02 13:39 - 8 comments
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Fibrinogen, coagulation factors VII (FVII) and VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Common ...- 2014-12-20 20:29 - 1 comment
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... QRS duration, a measure of ventricular depolarization and conduction, is associated with increased cardiovascular ... QRS duration in 13,031 African Americans from ten cohorts and conducted a transethnic GWAS meta-analysis with ... in high linkage disequilibrium with rs3922844 (r2 = 0.93) and was also in SCN5A intron 16. Transethnic GWAS ...- 2014-12-19 11:09
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... pressure (BP) is a major risk factor for cardiovascular disease. More than 60 loci in the genome have been ... previously; most are non-coding, have small effects on BP, and even in aggregate they explain only a small proportion ... variation in BP, we conducted discovery association and meta-analyses of single variant-based and gene-based ...- 2014-12-16 11:34
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... of these variants with obesity traits. Methods: 32 BMI- and 14 waist-hip ratio (WHR)-associated SNPs were genotyped ... predisposition and obesity traits were stronger with a healthier diet. Interpretation: While these data show modest ... are small, which likely limits their relevance for public health interventions. dietary patterns Genetics obesity ...- 2014-12-12 15:20