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... is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with ... C-reactive protein (hsCRP), fibrinogen, leucocyte count, and CCA-IMT was available in 20 prospective cohort studies ... 49,097 participants free of pre-existing cardiovascular disease. Study-specific estimates of associations were ...- 2014-03-21 04:34
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... variants in 1393 persons with late-onset Alzheimer’s disease (LOAD) and 8141 cognitively intact controls from four population-based cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ...- 2014-08-15 12:49
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... the most significant genetic risk factor for of Alzheimer disease (AD) and may mask effects of other loci. Methods We re-analyzed ... Project (IGAP) Consortium in APOE ε4+ (10,246 cases and 11,924 controls) and APOE ε4- (7,231 cases and 19,603 ...- 2014-08-08 12:01
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Abstract Background and purpose Because of a low prevalence of severe carotid ... Atherosclerosis Progression Study, and Cardiovascular Health Study; totaling 23,706 participants) were pooled. ... for overfitting. Results Age, sex, history of vascular disease, systolic and diastolic blood pressure, TC/HDL ...- 2014-07-30 12:27
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... to coordinate movement, memory, motivation, reinforcement and learning. To investigate how common genetic variants ... studies (GWAS) of the volumes of seven subcortical regions and intracranial volume, derived from magnetic resonance ... in intracerebral hemorrhage (ch1q22), Huntington’s disease (chr2p21), neuro-inflammation (chr2p21), ...- 2014-06-05 11:36
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... Histidine is a semi-essential amino acid with anti-oxidant and anti-inflammatory properties. Few data are available on ... the associations between genetic variants, histidine levels and incident coronary heart disease (CHD) in a population-based sample. Methods and ...- 2014-04-15 09:42
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... with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that such ... to investigate the inbreeding effects on traits of public health importance by measuring the overall length of ... whereas many important risk factors for late-onset complex diseases have not. inbreeding depression Genetics CHARGE ...- 2014-09-05 18:02
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... QRS duration, a measure of ventricular depolarization and conduction, is associated with increased cardiovascular ... QRS duration in 13,031 African Americans from ten cohorts and conducted a transethnic GWAS meta-analysis with ... in high linkage disequilibrium with rs3922844 (r2 = 0.93) and was also in SCN5A intron 16. Transethnic GWAS ...- 2014-12-19 11:09
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... Circulating omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with concentrations of ... : We evaluated interactions between common genetic variants and fatty acid intakes for the outcomes of circulating ...- 2014-04-13 16:04
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... The relationship between PVC frequency, incident CHF, and mortality in the general population remains unknown. METHODS We studied all Cardiovascular Health Study (CHS) participants randomly assigned to 24-hour ambulatory electrocardiography ...- 2014-04-18 20:35