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Associations between a physiologic index of comorbidity, putative biomarkers of aging, and mortality
... we began to look at methods to combine markers of aging and age-related disease and developed the concept of a subclinical, ... emphasizing the need to measure multiple systems to define healthy aging. In total, these observations suggest that ...- 2014-03-07 14:42 - 3 comments -
social networks Brain MRI abnormalities ROI brain health 1. Introduction [Rationale and background]: Several observational studies have found ... a longitudinal population-based study of coronary heart disease and stroke risk in community-dwelling adults 65 ...- 2014-01-29 17:17 - 5 comments
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... TGF-β levels may be a risk factor for chronic kidney disease (CKD) in older adults. It is unknown if increased ... who participated in the 1996/97 visit of the Cardiovascular Health Study (CHS). Prevalent CKD was defined as eGFR< 60 ... the participants was 78 ± 5 years, 40% (n=692) were male, and 22% (n=383) were black. 436 participants (25.3%) had ...- 2014-06-25 15:11 - 2 comments
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... the relationship between TSH, free thyroxine (FT4), and total T3 concentrations and adverse outcomes in older ... 65 years and over (n=360) enrolled in the Cardiovascular Health Study and taking levothyroxine. Main Outcome ... hip fracture, atrial fibrillation, dementia, coronary heart disease (CHD), heart failure, and all-cause death. Results: ...- 2014-05-16 13:41 - 1 comment
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... Wei-Lin-Weissfeld method Introduction [Rationale and background]: In 1980, James Fries proposed the ... into a shorter span between the increasing age at onset of disease and the fixed limit of lifespan. Fries’ ... stated that the successes of modern medicine and public health have resulted in prolonging life with advanced ...- 2014-07-18 08:56
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... between thyroid function tests within the euthyroid range and adverse outcomes in older adults. Methods: Men and women aged 65 and older enrolled in the Cardiovascular Health Study whose thyrotropin (TSH), free thyroxine (FT4), ... 1 hip fracture, 2 , 3 dementia, 4 coronary heart disease, 5 lipids, 6 blood pressure, 7 BMI, 8 , 9 and mortality. 10 ...- 2014-03-20 17:08 - 1 comment
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... outcomes. New conventions for defining cardiovascular disease events have already emerged. Objective: To compare ... methods of defining events in terms of event rates and risk-factor associations. Design, setting and ... aged 65 years and older recruited into the Cardiovascular Health Study in 1989-1993 and followed for cardiovascular ...- 2014-07-15 18:15 - 2 comments
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... a drug target can mimic pharmacological action of a drug and can be used to infer the probable clinical efficacy of ... also tested the association of carrier status with plasma lipids. RESULTS: In the discovery study, we identified four ... sequencing in the discovery study, and the Women’s Health Initiative (WHI). 14 All participants underwent a ...- 2014-05-13 21:58
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... compression of morbidity Introduction [Rationale and background]: There is surprisingly little data on end ... economic and policy implications.In the Cardiovascular Health Study, where 69% of participants have died by Year 18 ... socio-demographic factors, lifestyle factors and chronic disease status at baseline. A longer lifespan will be ...- 2014-05-29 13:19 - 4 comments
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... increases the subsequent risk of cardiovascular disease (CVD, new-onset heart failure, myocardial ... to other more traditional risk factors such as diabetes and hypertension. The mechanisms by ... these analyses using data from the Cardiovascular Health Study (CHS) and the Multi-Ethnic Study of ...- 2014-05-29 11:17