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... an endogenous inhibitor 25-hydroxyvitamin-D-1α-hydroxylase and decreases 1,25(OH) 2 D production. Thus, higher ... hospitalizations of 8.6 years. Setting: The Cardiovascular Health Study conducted in four U.S. communities. ... associations differed by the presence of chronic kidney disease (CKD) (eGFR CysC <60 ml/min/1.73m 2 [n=832] or urine ...- 2014-02-08 11:46 - 4 comments
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... thromboembolism (VTE) but results are inconsistent. Purpose and Study Selection: We conducted a systematic review and meta-analysis of epidemiologic studies to quantify the association between DM and VTE (deep vein thrombosis or pulmonary embolism). Data ...- 2014-08-27 12:02 - 6 comments
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... Inhibitors Adverse effects physical activity Aged Aged--80 and over Background The usage of statins rose ... for the primary and secondary prevention of cardiovascular disease. 1,2 The 2013 ACC/AHA guidelines on cardiovascular ... because of concurrent CHD and CHD risk factors, with the Health ABC study reporting statin use in 39.1% of its ...- 2014-11-20 14:22 - 3 comments
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... (uUMOD) is the most commonly secreted tubular protein in healthy adults. Genetic studies demonstrate that ... in the UMOD gene are associated with risk of chronic kidney disease. The relationship between concentration of uUMOD with decline in kidney function and cardiovascular disease (CVD), however, has not been well ...- 2014-01-27 07:37
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race ANP Introduction [Rationale and background] Natriuretic peptides (NP) are hormones with ... and aim to test this hypothesis in the Cardiovascular Health Study, which is a large, prospective observational ... and other traditional risk factors for cardiovascular disease, have significantly lower levels of circulating ...- 2014-08-21 20:37 - 3 comments
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Background Candidate gene and genome-wide association studies have ... targets for therapy. Funding The National Institutes of Health (NIH) National Heart, Lung, and Blood Institute ... RC2-HL-102923 (LungGO), and RC2-HL-102924 (Women's Health Initiative Sequencing Project, WHISP). Exome ...- 2014-01-06 11:00
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... of this study was to examine the relationship between sCD14 and osteoporotic fractures. Methods: In the Cardiovascular Health Study, 5,462 men and women had sCD14 levels measured ... When models were fully adjusted for demographics, lifestyle factors, and medication use, these associations were ...- 2014-11-20 05:39 - 6 comments
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... may be an important next step for optimizing VTE prevention and treatment. “Lifetime risk” is an easily ... two large, prospective cohort studies: the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in ... the factor V Leiden (17.1%), or with sickle cell trait or disease (18.2%). Lifetime risk estimates differed by cohort; ...- 2014-12-02 13:39 - 8 comments
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... retinopathy (DR) is a major complication of diabetes and the most frequent cause of blindness among working-age ... and directly integrated into membrane phosopholipids, which dislodges the inflammatory effects of omega-6 ... pressure, LDL cholesterol, hypertension, coronary artery disease, history of stroke. BRIEF ANALYSIS PLAN AND ...- 2014-04-03 14:11 - 3 comments
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... mobility disability older adults 1. Introduction [Rationale and background]: <br><br> Incident disability rates in older ... one cannot identify the phase of the dynamic process of disease that is undergoing change. In contrast, a decrease ... planning of clinical trials to prevent disability, aid in health policy and planning and also be useful in estimating ...- 2014-07-08 15:21