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... inflammation latent variable models unknown gold standard 1. Introduction [Rationale and background]: As ... ADL disability and death. We plan to use the Cardiovascular Health Study (CHS) for our projects because of its large ... blood pressure, history of diabetes, coronary heart disease, heart failure, arthritis, stroke, and dementia, ...- 2014-10-28 17:25 - 4 comments
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... associated with robust “normal” functional, structural, and molecular changes that underlie declines in cognition, ... neurological (i.e. neuropsychiatric and neurodegenerative) diseases (3). Importantly, we show that molecular aging of ... mobility (gait speed). Using data from the Dynamics of Healthy Aging and Body Composition Study (HealthABC), we ...- 2014-01-29 14:41 - 7 comments
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... risk factors 1. Introduction [Rationale and background]:Venous thromboembolism (VTE) is a substantial public health concern. Data from the United States shows that ... arterial thromboembolism (ATE), comprising coronary heart disease, stroke or transient cerebral ischaemic attack, and ...- 2014-03-18 12:02 - 2 comments
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... (elevated at neither of the two most recent assessments) and that the stroke risk would be intermediate among ... Methods: We used 11 years of data from the Cardiovascular Health Study with 4,319 participants without stroke at ... during physical activity including chores, obesity, heart diseases, hypertension, diabetes, and cognitive function. ...- 2014-11-10 13:09 - 3 comments
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... warranted. Methods: The relationship between glucose levels and UMI was examined in the Cardiovascular Health Study (CHS): a cohort study of individuals aged ≥ 65 years old. Those with prior coronary heart disease (CHD) or a UMI on initial ECG were excluded. The ...- 2014-11-30 09:59 - 6 comments
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Elevated fasting glucose (FG) and insulin (FI) levels are both capturing pathways that lead to type 2 diabetes (T2D) – hyperglycaemia and insulin resistance. To test the role of coding variation ... we used the HumanExome BeadChip in up to 60,564 individuals and followed up findings in 14,494 (T2D) cases and 80,277 ...- 2014-04-02 11:34
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Fibrinogen, coagulation factors VII (FVII) and VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Common ...- 2014-12-20 20:29 - 1 comment
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Objective: To examine whether dietary intake and sleep duration modify the association between ... CRY2 -rs11605924, MTNR1B -rs1387153, rs10830963; and NR1D1 -rs2314339) and glycemic traits, fasting glucose (FG) and HOMA-IR, ...- 2014-10-21 14:01 - 1 comment
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Background: The short and long-term risks of cardiovascular disease (CVD) after infection are poorly understood. ... cohorts with 21-year follow-up: Cardiovascular Health Study (CHS, n=5,888, initial age 65 years or older) ...- 2014-04-02 07:18
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... provide insight into a wide range of physiological states and exhibit moderate to high heritability, making them excellent candidates for genetic studies to inform underlying biologic ... associated with primary disorders as well as cardiovascular disease. These traits are highly heritable, yet many causal ...- 2014-10-10 06:07 - 4 comments