... form, that serves as a co-receptor for bacterial endotoxin and plays a key role in inflammation. Soluble CD14 (sCD14) ... participants in the population-based Cardiovascular Health Study without preexisting HF and available baseline ... to identify strategies for prevention of this fatal disease. Prevention strategies stem from better ...
... factor XI antigen (FXI), peak thrombin generation, and platelet count among participants in the Cardiovascular Health Study, an ongoing cohort study of older adults who ... risk. Despite their associations with cardiovascular disease, these biomarkers may not reflect pathophysiology ...
... Although assessment of ASCVD risk is crucial for prevention and management, the performance of the Pooled Cohort ... adults 65 years and older from the Cardiovascular Health Study, we calculated the 10-year risk of hard ASCVD ... females +1.5%). LCA identified four patterns: minimal disease (61.6%), cardio-metabolic (7.2%), low cognition ...
... L1 gene ( APOL1 ) are strongly associated with kidney disease in African Americans. This study assessed whether ... genotype was also associated with cardiovascular diseaseand death. Methods: An individual participant meta-analysis ... genotypes with adjudicated cardiovascular disease events and death in 22,935 African Americans from eight cohorts. ...
... cardiovascular mortality 1. Introduction [Rationale and background]: Cardiovascular disease is a leading cause of morbidity and mortality ... stroke and MI) and vascular mortality in the Cardiovascular Health Study (CHS). We expect that variability in total ...
... (1-4). They reflect also consumption of grain products and sugar (5)as well as endogenous fatty acid metabolism, ... from different compartments including serum/plasma phospholipids (PL), cholesterol esters (CE), triglycerides (TG) and ... Study (study-specific analyses) : Cardiovascular Health Study In the NIH-funded ancillary study ...
Importance: High throughput genotyping and sequencing across the genome may identify secondary ... genetic findings with evidence of association with disease risk or treatment response. The population prevalence and clinical significance of secondary findings is largely ...
... resonance imaging are common in the aging population and are part of the spectrum of vascular and neurodegenerative disease associated with brain aging. Though WMH are highly ...