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Non-esterified fatty acids frailty disability mobility limitation Background and rationale Non-esterified ... levels of NEFAs, and profiles thereof, are potentially modifiable and hence attractive candidates to study as risk ... inhibitors of lipolysis (e.g., adiponectin, insulin), and modifiable external factors (e.g., exercise, and dietary fat ...- 2019-09-10 13:17 - 1 comment
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... horizons ranging from 500 through 10000 days of follow up. Models were compared on a 20% held-out testing set using ... was performed for Random Forest and L1 Regression models across timepoints. We compared results with the ... were 813 incident myocardial infarction events. The ML models were most predictive over moderate follow up time ...- 2019-09-24 15:09 - 3 comments
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... significant source of morbidity and mortality. The gut microbiome and microbiota-derived trimethylamine N-oxide (TMAO) ... ECGs. Time-varying multivariable Cox proportional hazard models were used to assess associations of plasma ... CVD risks in multiple clinical cohorts, and both animal models with microbial transplantation and various studies on ...- 2019-09-04 13:20 - 4 comments
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... enhanced version of the Cardiovascular Disease (CVD) Policy Model, called the CKD Policy Model . The CVD Policy Model is a validated state-transition ... systolic blood pressure (SBP), body mass index (BMI), hemoglobin A1c (A1c), LDL, HDL, triglycerides, total cholesterol, ...- 2019-02-27 10:12
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... ability during aging require attention. A variety of modifiable risk factors including depression, diabetes, ... Alzheimer’s disease, influenza infection in murine models led to cognitive changes (Jurgens et al., 2012) and ... that APOE ε4 genotype interacts with various exposures to modify dementia risk. For example, the association of ...- 2019-05-21 09:43 - 4 comments
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... We used Cox proportional hazards regression models to determine associations with time-to-first ... 21339 hospitalizations during follow-up. In fully adjusted models, NEFAs were significantly associated with higher risk ... degree, from food or phospholipids. They are highly hydrophobic and carried by albumin in circulation prior to ...- 2019-01-07 20:55 - 2 comments
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... muscle mass and strength. gerokines Aging GDF8 myostatin mobility death Peter Ganz, Nathan LeBrasseur, Steve Cummings, ... prior to including them as outcomes in linear regression models. Covariates: GDF11 and GF8 will initially be analyzed separately. Then, we will include both in the same model. All models will be adjusted for age, sex, race, body ...- 2019-12-13 14:30 - 3 comments
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... between the calcification exposure and the incidence of moderate/severe AS in three nested models including variables associated with atherosclerosis ... of AS. Results: Strong positive associations with incident moderate/severe AS were found for all calcification sites ...- 2019-02-14 13:06 - 1 comment
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... used linear regression and inverse probability weighting to model telomere length as a function of NEFAs with adjustment ... race, and clinic site (β=-0.034; SE=0.015; P =0.02). Models remained similar in fully adjusted models where each ... degree, from food or phospholipids. They are highly hydrophobic and carried by albumin in circulation prior to ...- 2019-04-23 14:44
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... Group: Aim 1: Identify common genetic variants that modulate the relationship between five circulating omega-3 ... contributions of low frequency/rare genetic variants that modulate the relationship between five circulating omega-3 ... in previous CHARGE publications. Linear regression models of the form: Model 1: y(biomarker) =α + ...- 2019-04-29 09:52 - 2 comments