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Background: Uromodulin is released by tubular epithelial cells into the serum (sUMOD) and lower levels are associated with more severe ... (IF/TA). Little is known about the association of sUMOD with long-term kidney outcomes in older adults, a ...- 2018-07-10 05:19
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We construct non-linear Machine Learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) ... and polygenic risk scores (PRSs). We developed two-models ensemble, consisting of a baseline model, where prediction is based on demographic variables ...- 2023-08-11 11:03
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UMOD is a major risk gene for monogenic and complex forms of kidney disease. The encoded protein uromodulin is highly abundant in urine and related to kidney ... defense. We performed genome-wide screens of circulating uromodulin (N=32,055) to identify pathway members and study ...- 2021-07-08 11:15
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... of FH gene mutations on CHD risk among individuals with moderately elevated LDL-C has not been well quantified. ... CHD associated with FH mutations among individuals with moderately (LDL-C 130-189 mg/dL) and severely elevated LDL-C ... Main Outcomes and Measures: Cox proportional hazards models estimated associations between FH mutations and ...- 2023-05-19 13:33
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... from a median 13 years of follow-up. Risk prediction models using cumulative means of the repeat measures and summary measures from longitudinal modelling of the repeat measures were compared to models using measures from a single time point. Risk ...- 2016-05-26 12:38
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... is still being understood. Understanding which CAD loci are moderated by T2D in the development of coronary artery ... We included first-order T2D interaction terms in each model to determine which CAD loci were moderated by T2D. The genetic main and interaction effects ...- 2023-01-26 08:40
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... using a large, multiethnic dataset and liability threshold modeling of duration of diabetes and glycemic control to ... for Caucasians and African Americans. Liability threshold modeling of two clinical covariates, glycemic control and ... Study of Diabetic Retinopathy using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control ...- 2018-01-22 11:25
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... across ancestry groups and emphasize the importance of modelling heterogeneity in allelic effects on disease in ... Trans-ancestry genetic study of type 2 diabetes: a model for common diseases ...- 2020-05-20 11:40
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... to dyslipidemia. We hypothesized that SSB intake may modify the associations between CHREBP variants and ... the UK Biobank (N=59,220) using similar linear regression models where participants were classified as SSB consumers ... near the CHREBP locus and lipoprotein concentrations may be modified by sugar-sweetened beverage consumption ...- 2020-08-19 16:18
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n/a (research letter not containing an abstract) uromodulin Tamm-Horsfall-Protein tubular function chronic ... regression Associations between serum and urinary uromodulin and each their correlates in older adults – the ...- 2019-08-27 14:43 - 1 comment