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Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Corporate/Institutional Authors | CRP CHD Genetics Collaboration, |
| Journal | Eur J Epidemiol |
| Volume | 23 |
| Issue | 8 |
| Pagination | 531-40 |
| Date Published | 2008 |
| ISSN | 0393-2990 |
| Keywords | C-Reactive Protein, Case-Control Studies, Cooperative Behavior, Coronary Disease, Haplotypes, Humans, Inflammation, Polymorphism, Genetic, Research Design |
| Abstract | <p>Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.</p> |
| DOI | 10.1007/s10654-008-9249-z |
| Alternate Journal | Eur J Epidemiol |
| PubMed ID | 18425592 |
| PubMed Central ID | PMC: N/A |
| Grant List | RG/08/008/25291 / / British Heart Foundation / United Kingdom G0600705 / / Medical Research Council / United Kingdom RG/08/014/24067 / / British Heart Foundation / United Kingdom MC_U137686857 / / Medical Research Council / United Kingdom G0401527 / / Medical Research Council / United Kingdom MC_U105260792 / / Medical Research Council / United Kingdom |