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Race, gender, and mortality in adults > or =65 years of age with incident heart failure (from the Cardiovascular Health Study).
Tuesday,2012-11-06 12:10 America/Los_Angeles — eenright
| Title | Race, gender, and mortality in adults > or =65 years of age with incident heart failure (from the Cardiovascular Health Study). |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Parashar, S, Katz, R, Smith, NL, Arnold, AM, Vaccarino, V, Wenger, NK, Gottdiener, JS |
| Journal | Am J Cardiol |
| Volume | 103 |
| Issue | 8 |
| Pagination | 1120-7 |
| Date Published | 2009 Apr 15 |
| ISSN | 1879-1913 |
| Keywords | African Americans, Age Factors, Aged, Aged, 80 and over, Cohort Studies, Continental Population Groups, European Continental Ancestry Group, Female, Heart Failure, Humans, Incidence, Male, Proportional Hazards Models, Sex Factors, United States |
| Abstract | <p>In patients with heart failure (HF), mortality is lower in women versus men. However, it is unknown whether the survival advantage in women compared with men is present in both whites and African Americans with HF. The inception cohort consisted of adults > or =65 years with incident HF after enrollment in the CHS, a prospective population-based study of cardiovascular disease. Of 5,888 CHS subjects, 1,264 developed new HF and were followed up for 3 years. Subjects were categorized into 4 race-gender groups, and Cox proportional hazard regression models were used to examine whether 3-year total and cardiovascular mortality differed among the 4 groups after adjusting for sociodemographic factors, co-morbidities, and treatment. A gender-race interaction was also tested for each outcome. In subjects with incident HF, African Americans had more hypertension and diabetes than whites, and white men had more coronary heart disease than other gender-race groups. Receipt of cardiovascular treatments among the 4 groups was similar. Mortality rates after HF were lower in women compared with men (for white women, African-American women, African-American men, and white men, total mortality was 35.5, 33.6, 44.4, and 40.5/100 person-years, and cardiovascular mortality was 18.4, 19.5, 20.2, and 22.7/100 person-years, respectively). After adjusting for covariates, women had a 15% to 20% lower risk of total and cardiovascular mortality compared with men, but there was no significant difference in outcome by race. The gender-race interaction for either outcome was not significant. In conclusion, in older adults with HF, women had significantly better survival than men irrespective of race, suggesting that gender-based survival differences may be more important than race-based differences.</p> |
| DOI | 10.1016/j.amjcard.2008.12.043 |
| Alternate Journal | Am J Cardiol |
| PubMed ID | 19361600 |
| PubMed Central ID | PMC4122325 |
| Grant List | N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States 1K23RR023171 / RR / NCRR NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States |