You are here
Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis.
Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
| Title | Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | de Weerd, M, Greving, JP, Hedblad, B, Lorenz, MW, Mathiesen, EB, O'Leary, DH, Rosvall, M, Sitzer, M, Buskens, E, Bots, ML |
| Journal | Stroke |
| Volume | 41 |
| Issue | 6 |
| Pagination | 1294-7 |
| Date Published | 2010 Jun |
| ISSN | 1524-4628 |
| Keywords | Adult, Age Factors, Aged, Aged, 80 and over, Carotid Stenosis, Female, Humans, Male, Mass Screening, Middle Aged, Prevalence, Severity of Illness Index, Sex Factors |
| Abstract | <p><b>BACKGROUND AND PURPOSE: </b>In the discussion on the cost-effectiveness of screening, precise estimates of severe asymptomatic carotid stenosis are vital. Accordingly, we assessed the prevalence of moderate and severe asymptomatic carotid stenosis by age and sex using pooled cohort data.</p><p><b>METHODS: </b>We performed an individual participant data meta-analysis (23 706 participants) of 4 population-based studies (Malmö Diet and Cancer Study, Tromsø, Carotid Atherosclerosis Progression Study, and Cardiovascular Health Study). Outcomes of interest were asymptomatic moderate (> or =50%) and severe carotid stenosis (> or =70%).</p><p><b>RESULTS: </b>Prevalence of moderate asymptomatic carotid stenosis ranged from 0.2% (95% CI, 0.0% to 0.4%) in men aged <50 years to 7.5% (5.2% to 10.5%) in men aged > or =80 years. For women, this prevalence increased from 0% (0% to 0.2%) to 5.0% (3.1% to 7.5%). Prevalence of severe asymptomatic carotid stenosis ranged from 0.1% (0.0% to 0.3%) in men aged <50 years to 3.1% (1.7% to 5.3%) in men aged > or =80. For women, this prevalence increased from 0% (0.0% to 0.2%) to 0.9% (0.3% to 2.4%).</p><p><b>CONCLUSIONS: </b>The prevalence of severe asymptomatic carotid stenosis in the general population ranges from 0% to 3.1%, which is useful information in the discussion on the cost-effectiveness of screening.</p> |
| DOI | 10.1161/STROKEAHA.110.581058 |
| Alternate Journal | Stroke |
| PubMed ID | 20431077 |
| PubMed Central ID | PMC4254855 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |