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Hemodynamic fluid shear stress response genes and carotid intima-media thickness: a candidate gene association analysis in the cardiovascular health study.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | Hemodynamic fluid shear stress response genes and carotid intima-media thickness: a candidate gene association analysis in the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Suchy-Dicey, AM, Enquobahrie, DA, Heckbert, SR, Rotter, JI, Psaty, BM, McKnight, B |
| Journal | Int J Mol Epidemiol Genet |
| Volume | 3 |
| Issue | 2 |
| Pagination | 174-8 |
| Date Published | 2012 |
| ISSN | 1948-1756 |
| Abstract | <p><b>OBJECTIVE: </b>This study examined whether carotid artery intimal-medial thickness (cIMT) is associated with genetic variations (SNPs) in a hemodynamics-responsive gene pathway.</p><p><b>METHODS: </b>Subjects were Cardiovascular Health Study participants free of cardiovascular events at baseline (N=3388). Genotype was measured using Illumina 370CNV HumanHap chip. Carotid IMT was measured using ultrasound. Estimated mean differences in cIMT per additional minor allele for 366 SNPs in MAP2K5, MAPK7, MEF2A/C, and KLF2 were adjusted for sex, age, clinic, and medication use. SNP-SNP interactions were examined using logic regression for 71 tagSNPs.</p><p><b>RESULTS: </b>None of the associations was significant after correction for multiple comparisons; smallest P-value=0.065 for MAP2K5 and common cIMT. The best-performing logic regression tree combined two SNPs in MAP2K5-rs745212 and rs12905175- and common cIMT; this association was not significant, corrected P-value=0.062.</p><p><b>CONCLUSION: </b>There was not strong evidence of association between genetic variants in a hemodynamics-responsive gene pathway and atherosclerosis among older adults.</p> |
| Alternate Journal | Int J Mol Epidemiol Genet |
| PubMed ID | 22724054 |
| PubMed Central ID | PMC3376916 |
| Grant List | P30 DK063491 / DK / NIDDK NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States |