You are here
Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults.
Monday,2013-01-14 16:55 America/Los_Angeles — poolea2
| Title | Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | deFilippi, CR, de Lemos, JA, Tkaczuk, AT, Christenson, RH, Carnethon, MR, Siscovick, DS, Gottdiener, JS, Seliger, SL |
| Journal | J Am Coll Cardiol |
| Volume | 60 |
| Issue | 24 |
| Pagination | 2539-47 |
| Date Published | 2012 Dec 18 |
| ISSN | 1558-3597 |
| Keywords | Aged, Biomarkers, Female, Heart Failure, Humans, Male, Motor Activity, Natriuretic Peptide, Brain, Peptide Fragments, Risk Assessment, Troponin |
| Abstract | <p><b>OBJECTIVES: </b>The aim of this study was to evaluate the association between physical activity and changes in levels of highly sensitive troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), and the subsequent risk of the development of heart failure (HF) in community-dwelling older adults.</p><p><b>BACKGROUND: </b>Higher baseline levels of cTnT and NT-proBNP and increases over time correlate with the risk of HF in older adults. Factors modifying these levels have not been identified.</p><p><b>METHODS: </b>NT-proBNP and cTnT were measured at baseline and 2 to 3 years later in adults 65 years of age and older free of HF participating in the Cardiovascular Health Study. Self-reported physical activity and walking pace were combined into a composite score. An increase was prespecified for NT-proBNP as a >25% increment from baseline to ≥190 pg/ml and for cTnT as a >50% increment from baseline in participants with detectable levels (≥3 pg/ml).</p><p><b>RESULTS: </b>A total of 2,933 participants free of HF had NT-proBNP and cTnT measured at both time points. The probability of an increase in biomarker concentrations between baseline and follow-up visits was inversely related to the physical activity score. Compared with participants with the lowest score, those with the highest score had an odds ratio of 0.50 (95% confidence interval: 0.33 to 0.77) for an increase in NT-proBNP and an odds ratio of 0.30 (95% confidence interval: 0.16 to 0.55) for an increase in cTnT, after adjusting for comorbidities and baseline levels. A higher activity score associated with a lower long-term incidence of HF. Moreover, at each level of activity, an increase in either biomarker still identified those at higher risk.</p><p><b>CONCLUSIONS: </b>These findings suggest that moderate physical activity has protective effects on early heart failure phenotypes, preventing cardiac injury and neurohormonal activation.</p> |
| DOI | 10.1016/j.jacc.2012.08.1006 |
| Alternate Journal | J. Am. Coll. Cardiol. |
| PubMed ID | 23158528 |
| PubMed Central ID | PMC3591516 |
| Grant List | R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States |