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Frequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health Study.

TitleFrequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health Study.
Publication TypeJournal Article
Year of Publication2001
AuthorsLongstreth, WT, Bernick, C, Fitzpatrick, A, Cushman, M, Knepper, L, Lima, J, Furberg, CD
JournalNeurology
Volume56
Issue3
Pagination368-75
Date Published2001 Feb 13
ISSN0028-3878
KeywordsAged, Aged, 80 and over, Clinical Trials as Topic, Female, Humans, Longitudinal Studies, Male, Predictive Value of Tests, Stroke, Survival Analysis, United States
Abstract<p><b>BACKGROUND: </b>Few population-based studies have examined in detail issues of stroke-related deaths in elderly people.</p><p><b>METHODS: </b>Participants in the Cardiovascular Health Study (CHS) are 65 years of age or older, have had extensive baseline evaluations, and have been followed-up for fatal and nonfatal cardiovascular and cerebrovascular disease outcomes. Investigators adjudicated these outcomes and classified strokes by types and subtypes.</p><p><b>RESULTS: </b>Over 7 years, 1,310 (22.2%) of 5,888 participants died, and 455 (7.7%) experienced incident stroke. For the 5,888, stroke mortality was 3.2 per 1,000 person-years. For the 455, it was 36.1 per 1,000 person-years, with the most lethal type being hemorrhagic and the ischemic subtype being cardioembolic. After controlling for age and stroke type, the only other independent predictor of death after any stroke was poor performance on a timed walk measured before the incident stroke. Considering only ischemic stroke, the independent predictors of death were African American race and poor performance on timed walk.</p><p><b>CONCLUSION: </b>In CHS, death attributable to stroke is common. As in other studies, the most lethal stroke type was hemorrhagic, and ischemic stroke subtype, cardioembolic. Slow walking, possibly a measure of frailty, was associated with an increased risk of death of stroke. Finally, African Americans faced a greater risk of death than others after an ischemic stroke.</p>
DOI10.1212/wnl.56.3.368
Alternate JournalNeurology
PubMed ID11171903
Grant ListHL 15103 / HL / NHLBI NIH HHS / United States
HL 35129 / HL / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States