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Dietary protein intake and change in estimated GFR in the Cardiovascular Health Study.
Wednesday,2015-03-04 11:55 America/Los_Angeles — zdrager
| Title | Dietary protein intake and change in estimated GFR in the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Beasley, JM, Katz, R, Shlipak, M, Rifkin, DE, Siscovick, D, Kaplan, R |
| Journal | Nutrition |
| Volume | 30 |
| Issue | 7-8 |
| Pagination | 794-9 |
| Date Published | 2014 Jul-Aug |
| ISSN | 1873-1244 |
| Keywords | Aged, Aging, Diet, Dietary Proteins, Feeding Behavior, Female, Glomerular Filtration Rate, Health, Humans, Kidney, Male, Regression Analysis, Surveys and Questionnaires |
| Abstract | <p><b>OBJECTIVE: </b>With aging, kidney function declines, as evidenced by reduced glomerular filtration rate. It is controversial whether or not high protein intake accelerates this decline. The aim of this study was to determine whether high protein intake was associated with declines in kidney function among older patients.</p><p><b>METHODS: </b>We examined whether dietary protein is associated with change in kidney function (mean follow-up 6.4 y [SD = 1.4, range = 2.5-7.9] in the Cardiovascular Health Study (N = 3623). We estimated protein intake using a food frequency questionnaire and estimated glomerular filtration rate from cystatin C. Associations between protein intake and kidney function were determined by linear and logistic regression models.</p><p><b>RESULTS: </b>Average protein intake was 19% of energy intake (SD = 5%). Twenty-seven percent (n = 963) of study participants had rapid decline in kidney function, as defined by (ΔeGFRcysC > 3 mL•min•1.73 m(2)). Protein intake (characterized as g/d and % energy/d), was not associated with change in estimated glomerular filtration rate (P > 0.05 for all comparisons). There were also no significant associations when protein intake was separated by source (animal and vegetable).</p><p><b>CONCLUSION: </b>These data suggest that higher protein intake does not have a major effect on kidney function decline among elderly men and women.</p> |
| DOI | 10.1016/j.nut.2013.12.006 |
| Alternate Journal | Nutrition |
| PubMed ID | 24984995 |
| PubMed Central ID | PMC4082792 |
| Grant List | N01 HC85079 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States 4 R00 AG035002 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC85083 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01 HC85086 / HC / NHLBI NIH HHS / United States UL1 TR001073 / TR / NCATS NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC85082 / HC / NHLBI NIH HHS / United States R00 AG035002 / AG / NIA NIH HHS / United States HHSN268200800007C / / PHS HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01 HC85080 / HC / NHLBI NIH HHS / United States HHSN268201200036C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States AG023629 / AG / NIA NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States |