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Orthostatic Hypotension and Risk of Venous Thromboembolism in 2 Cohort Studies.
Friday,2015-08-28 11:19 America/Los_Angeles — zdrager
| Title | Orthostatic Hypotension and Risk of Venous Thromboembolism in 2 Cohort Studies. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Bell, EJ, Agarwal, SK, Cushman, M, Heckbert, SR, Lutsey, PL, Folsom, AR |
| Journal | Am J Hypertens |
| Volume | 29 |
| Issue | 5 |
| Pagination | 634-40 |
| Date Published | 2016 May |
| ISSN | 1941-7225 |
| Abstract | <p><b>BACKGROUND: </b>Although venous stasis is a risk factor for venous thromboembolism (VTE) and orthostatic hypotension (OH) can cause venous stasis, to our knowledge no study has examined the relationship between OH and VTE risk. We sought to quantify the association between OH and VTE (deep vein thrombosis or pulmonary embolism) using data from 2 large, prospective cohort studies: the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study. We hypothesized that OH was positively associated with incident VTE.</p><p><b>METHODS: </b>We measured OH-defined as a drop in systolic blood pressure (SBP) of at least 20 mm Hg or diastolic blood pressure (DBP) of at least 10 mm Hg within 3 minutes of standing-in participants aged 45-64 years in ARIC (n = 12,480) and ≥65 years in CHS (n = 5,027) at baseline visits (1987-1989 in ARIC; 1989-1990 and 1992-1993 in CHS), and followed participants for incident VTE (n = 568 in ARIC through 2011 and n = 148 in CHS through 2001). We calculated adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) for incident VTE in relation to OH status.</p><p><b>RESULTS: </b>In CHS, there was a positive association between OH status and incident VTE (HR for VTE = 1.74 (95% CI: 1.20-2.51)). In contrast, there was no association between OH and VTE in the ARIC study (HR for VTE = 0.97 (95% CI: 0.70-1.33)).</p><p><b>CONCLUSIONS: </b>Community-dwelling older adults with OH had a moderately increased risk of VTE. These results were not seen in a population-based middle-aged cohort.</p> |
| DOI | 10.1093/ajh/hpv151 |
| Alternate Journal | Am. J. Hypertens. |
| PubMed ID | 26306405 |
| PubMed Central ID | PMC5014082 |
| Grant List | HHSN268200800007C / / PHS HHS / United States HHSN268201100005C / / PHS HHS / United States HHSN268201100006C / / PHS HHS / United States HHSN268201100007C / / PHS HHS / United States HHSN268201100008C / / PHS HHS / United States HHSN268201100009C / / PHS HHS / United States HHSN268201100010C / / PHS HHS / United States HHSN268201100011C / / PHS HHS / United States HHSN268201100012C / / PHS HHS / United States HHSN268201200036C / / PHS HHS / United States N01HC55222 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States T32 HL007779 / HL / NHLBI NIH HHS / United States T32HL007779 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States |