| Title | Multi-ethnic genome-wide association study for atrial fibrillation. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Roselli, C, Chaffin, MD, Weng, L-C, Aeschbacher, S, Ahlberg, G, Albert, CM, Almgren, P, Alonso, A, Anderson, CD, Aragam, KG, Arking, DE, Barnard, J, Bartz, TM, Benjamin, EJ, Bihlmeyer, NA, Bis, JC, Bloom, HL, Boerwinkle, E, Bottinger, EB, Brody, JA, Calkins, H, Campbell, A, Cappola, TP, Carlquist, J, Chasman, DI, Chen, LY, Chen, Y-DI, Choi, E-K, Choi, SHoan, Christophersen, IE, Chung, MK, Cole, JW, Conen, D, Cook, J, Crijns, HJ, Cutler, MJ, Damrauer, SM, Daniels, BR, Darbar, D, Delgado, G, Denny, JC, Dichgans, M, Dörr, M, Dudink, EA, Dudley, SC, Esa, N, Esko, T, Eskola, M, Fatkin, D, Felix, SB, Ford, I, Franco, OH, Geelhoed, B, Grewal, RP, Gudnason, V, Guo, X, Gupta, N, Gustafsson, S, Gutmann, R, Hamsten, A, Harris, TB, Hayward, C, Heckbert, SR, Hernesniemi, J, Hocking, LJ, Hofman, A, Horimoto, ARVR, Huang, J, Huang, PL, Huffman, J, Ingelsson, E, Ipek, EGucuk, Ito, K, Jimenez-Conde, J, Johnson, R, J Jukema, W, Kääb, S, Kähönen, M, Kamatani, Y, Kane, JP, Kastrati, A, Kathiresan, S, Katschnig-Winter, P, Kavousi, M, Kessler, T, Kietselaer, BL, Kirchhof, P, Kleber, ME, Knight, S, Krieger, JE, Kubo, M, Launer, LJ, Laurikka, J, Lehtimäki, T, Leineweber, K, Lemaitre, RN, Li, M, Lim, HEuy, Lin, HJ, Lin, H, Lind, L, Lindgren, CM, Lokki, M-L, London, B, Loos, RJF, Low, S-K, Lu, Y, Lyytikäinen, L-P, Macfarlane, PW, Magnusson, PK, Mahajan, A, Malik, R, Mansur, AJ, Marcus, GM, Margolin, L, Margulies, KB, März, W, McManus, DD, Melander, O, Mohanty, S, Montgomery, JA, Morley, MP, Morris, AP, Müller-Nurasyid, M, Natale, A, Nazarian, S, Neumann, B, Newton-Cheh, C, Niemeijer, MN, Nikus, K, Nilsson, P, Noordam, R, Oellers, H, Olesen, MS, Orho-Melander, M, Padmanabhan, S, Pak, H-N, Paré, G, Pedersen, NL, Pera, J, Pereira, A, Porteous, D, Psaty, BM, Pulit, SL, Pullinger, CR, Rader, DJ, Refsgaard, L, Ribasés, M, Ridker, PM, Rienstra, M, Risch, L, Roden, DM, Rosand, J, Rosenberg, MA, Rost, N, Rotter, JI, Saba, S, Sandhu, RK, Schnabel, RB, Schramm, K, Schunkert, H, Schurman, C, Scott, SA, Seppälä, I, Shaffer, C, Shah, S, Shalaby, AA, Shim, J, M Shoemaker, B, Siland, JE, Sinisalo, J, Sinner, MF, Slowik, A, Smith, AV, Smith, BH, J Smith, G, Smith, JD, Smith, NL, Soliman, EZ, Sotoodehnia, N, Stricker, BH, Sun, A, Sun, H, Svendsen, JH, Tanaka, T, Tanriverdi, K, Taylor, KD, Teder-Laving, M, Teumer, A, Thériault, S, Trompet, S, Tucker, NR, Tveit, A, Uitterlinden, AG, van der Harst, P, Van Gelder, IC, Van Wagoner, DR, Verweij, N, Vlachopoulou, E, Völker, U, Wang, B, Weeke, PE, Weijs, B, Weiss, R, Weiss, S, Wells, QS, Wiggins, KL, Wong, JA, Woo, D, Worrall, BB, Yang, P-S, Yao, J, Yoneda, ZT, Zeller, T, Zeng, L, Lubitz, SA, Lunetta, KL, Ellinor, PT |
| Journal | Nat Genet |
| Volume | 50 |
| Issue | 9 |
| Pagination | 1225-1233 |
| Date Published | 2018 Sep |
| ISSN | 1546-1718 |
| Abstract | <p>Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex heritability. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.</p> |
| DOI | 10.1038/s41588-018-0133-9 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 29892015 |
| PubMed Central ID | PMC6136836 |
| Grant List | R01 HL139731 / HL / NHLBI NIH HHS / United States
K24 HL105780 / HL / NHLBI NIH HHS / United States
L30 HL123413 / HL / NHLBI NIH HHS / United States
R01 HL092577 / HL / NHLBI NIH HHS / United States
R01 HL128914 / HL / NHLBI NIH HHS / United States
K23 HL127296 / HL / NHLBI NIH HHS / United States
2014105 / / Doris Duke Charitable Foundation / United States |
