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Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.
Wednesday,2018-10-03 18:38 America/Los_Angeles — ecterry
| Title | Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Lorenz, MW, Gao, L, Ziegelbauer, K, Norata, GDanilo, Empana, JPhilippe, Schmidtmann, I, Lin, H-J, McLachlan, S, Bokemark, L, Ronkainen, K, Amato, M, Schminke, U, Srinivasan, SR, Lind, L, Okazaki, S, Stehouwer, CDA, Willeit, P, Polak, JF, Steinmetz, H, Sander, D, Poppert, H, Desvarieux, M, Ikram, AM, Johnsen, SHarald, Staub, D, Sirtori, CR, Iglseder, B, Beloqui, O, Engström, G, Friera, A, Rozza, F, Xie, W, Parraga, G, Grigore, L, Plichart, M, Blankenberg, S, Su, T-C, Schmidt, C, Tuomainen, T-P, Veglia, F, Völzke, H, Nijpels, G, Willeit, J, Sacco, RL, Franco, OH, Uthoff, H, Hedblad, B, Suarez, C, Izzo, R, Zhao, D, Wannarong, T, Catapano, A, Ducimetiere, P, Espinola-Klein, C, Chien, K-L, Price, JF, Bergström, G, Kauhanen, J, Tremoli, E, Dörr, M, Berenson, G, Kitagawa, K, Dekker, JM, Kiechl, S, Sitzer, M, Bickel, H, Rundek, T, Hofman, A, Mathiesen, EB, Castelnuovo, S, Landecho, MF, Rosvall, M, Gabriel, R, de Luca, N, Liu, J, Baldassarre, D, Kavousi, M, de Groot, E, Bots, ML, Yanez, DN, Thompson, SG |
| Corporate/Institutional Authors | PROG-IMT Study Group, |
| Journal | PLoS One |
| Volume | 13 |
| Issue | 4 |
| Pagination | e0191172 |
| Date Published | 2018 |
| ISSN | 1932-6203 |
| Keywords | Aged, Cardiovascular Diseases, Carotid Intima-Media Thickness, Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Prognosis, Risk Factors |
| Abstract | <p><b>AIMS: </b>Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.</p><p><b>METHODS AND RESULTS: </b>From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C.</p><p><b>CONCLUSIONS: </b>We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.</p> |
| DOI | 10.1371/journal.pone.0191172 |
| Alternate Journal | PLoS ONE |
| PubMed ID | 29649236 |
| PubMed Central ID | PMC5896895 |
| Grant List | R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 DE013094 / DE / NIDCR NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R37 NS029993 / NS / NINDS NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States |
ePub date:
18/09