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Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.
Monday,2019-03-11 13:55 America/Los_Angeles — ecterry
| Title | Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Larsson, SC, Traylor, M, Burgess, S, Boncoraglio, GB, Jern, C, Michaëlsson, K, Markus, HS |
| Corporate/Institutional Authors | MEGASTROKE project of the International Stroke Genetics Consortium |
| Journal | Neurology |
| Volume | 92 |
| Issue | 9 |
| Pagination | e944-e950 |
| Date Published | 2019 Feb 26 |
| ISSN | 1526-632X |
| Abstract | <p><b>OBJECTIVE: </b>To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.</p><p><b>METHODS: </b>Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).</p><p><b>RESULTS: </b>In standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; = 1.3 × 10) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; = 1.6 × 10) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.</p><p><b>CONCLUSIONS: </b>This study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.</p> |
| DOI | 10.1212/WNL.0000000000007001 |
| Alternate Journal | Neurology |
| PubMed ID | 30804065 |
ePub date:
19/02