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Level and change in N-terminal pro B-type Natriuretic Peptide and kidney function and survival to age 90.
Monday,2020-08-24 17:13 America/Los_Angeles — ecterry
| Title | Level and change in N-terminal pro B-type Natriuretic Peptide and kidney function and survival to age 90. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Häberle, AD, Biggs, ML, Cushman, M, Psaty, BM, Newman, AB, Shlipak, MG, Gottdiener, J, Wu, C, Gardin, JM, Bansal, N, Odden, MC |
| Journal | J Gerontol A Biol Sci Med Sci |
| Date Published | 2020 May 17 |
| ISSN | 1758-535X |
| Abstract | <p><b>BACKGROUND: </b>Many traditional cardiovascular risk factors do not predict survival to very old age. Studies have shown associations of estimated glomerular filtration rate (eGFR) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with cardiovascular disease and mortality in older populations. This study aimed to evaluate the associations of the level and change in eGFR and NT-pro-BNP with longevity to age 90 years.</p><p><b>METHODS: </b>The population included participants (n=3,645) in the Cardiovascular Health Study, aged between 67-75 at baseline. The main exposures were eGFR, calculated with the Berlin Initiative Study equation (BIS2), and NT-pro-BNP, and the main outcome was survival to age 90. Mixed models were used to estimate level and change of the main exposures.</p><p><b>RESULTS: </b>There was an association between baseline level and change of both eGFR and NT-pro-BNP and survival to 90, and this association persisted after adjustment for covariates. Each 10 ml/min per 1.73 m2 higher eGFR level was associated with an adjusted odds ratio (OR) of 1.23 (95% CI: 1.13, 1.34) of survival to 90, and a 0.5 ml/min/ 1.73 m2 slower decline in eGFR was associated with an OR of 1.51 (95% CI: 1.31, 1.74). A 2-fold higher level of NT-pro-BNP level had an adjusted OR of 0.67 (95% CI: 0.61, 0.73), and a 1.05-fold increase per year in NT-pro-BNP had an OR of 0.53 (95% CI: 0.43, 0.65) for survival to age 90.</p><p><b>CONCLUSION: </b>eGFR and NT-pro-BNP appear to be important risk factors for longevity to age 90.</p> |
| DOI | 10.1093/gerona/glaa124 |
| Alternate Journal | J. Gerontol. A Biol. Sci. Med. Sci. |
| PubMed ID | 32417919 |
ePub date:
20/05