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Fish intake and risk of incident heart failure.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Fish intake and risk of incident heart failure. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Mozaffarian, D, Bryson, CL, Lemaitre, RN, Burke, GL, Siscovick, DS |
| Journal | J Am Coll Cardiol |
| Volume | 45 |
| Issue | 12 |
| Pagination | 2015-21 |
| Date Published | 2005 Jun 21 |
| ISSN | 0735-1097 |
| Keywords | Aged, Animals, Cohort Studies, Cooking, Diet, Diet Surveys, Disease-Free Survival, Female, Fishes, Heart Failure, Humans, Incidence, Male, Risk Factors, United States |
| Abstract | <p><b>OBJECTIVES: </b>Our aim was to investigate the relation between fish consumption and incidence of congestive heart failure (CHF).</p><p><b>BACKGROUND: </b>The incidence and health burden of CHF are rising, particularly in older persons. Although n-3 fatty acids have effects that could favorably influence risk of CHF, the relation between fish intake and CHF incidence is unknown.</p><p><b>METHODS: </b>Among 4,738 adults age > or =65 years and free of CHF at baseline in 1989-90, usual dietary intake was assessed using a food frequency questionnaire. In a participant subsample, consumption of tuna or other broiled or baked fish, but not fried fish, correlated with plasma phospholipid n-3 fatty acids. Incidence of CHF was prospectively adjudicated.</p><p><b>RESULTS: </b>During 12 years' follow-up, 955 participants developed CHF. In multivariate-adjusted analyses, tuna/other fish consumption was inversely associated with incident CHF, with 20% lower risk with intake 1 to 2 times/week (hazard ratio [HR] = 0.80, 95% confidence interval [CI] = 0.64 to 0.99), 31% lower risk with intake 3 to 4 times/week (HR = 0.69, 95% CI = 0.52 to 0.91), and 32% lower risk with intake > or =5 times/week (HR = 0.68, 95% CI = 0.45 to 1.03), compared with intake <1 time/month (p trend = 0.009). In similar analyses, fried fish consumption was positively associated with incident CHF (p trend = 0.01). Dietary long-chain n-3 fatty acid intake was also inversely associated with CHF (p trend = 0.009), with 37% lower risk in the highest quintile of intake (HR = 0.73, 95% CI = 0.57 to 0.94) compared with the lowest.</p><p><b>CONCLUSIONS: </b>Among older adults, consumption of tuna or other broiled or baked fish, but not fried fish, is associated with lower incidence of CHF. Confirmation in additional studies and evaluation of potential mechanisms is warranted.</p> |
| DOI | 10.1016/j.jacc.2005.03.038 |
| Alternate Journal | J Am Coll Cardiol |
| PubMed ID | 15963403 |
| Grant List | K08 HL 075628 / HL / NHLBI NIH HHS / United States N01 HC 15103 / HC / NHLBI NIH HHS / United States N01 HC 35129 / HC / NHLBI NIH HHS / United States N01 HC 85079 / HC / NHLBI NIH HHS / United States N01 HC 85086 / HC / NHLBI NIH HHS / United States |