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Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study.
Wednesday,2021-04-21 15:56 America/Los_Angeles — ecterry
| Title | Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Hwang, PH, Longstreth, WT, Thielke, SM, Francis, CE, Carone, M, Kuller, LH, Fitzpatrick, AL |
| Journal | Alzheimers Dement |
| Date Published | 2021 Mar 31 |
| ISSN | 1552-5279 |
| Abstract | <p><b>INTRODUCTION: </b>Ophthalmic conditions and dementia appear to overlap and may share common pathways, but research has not differentiated dementia subtypes.</p><p><b>METHODS: </b>Diagnoses of cataracts, age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma were based on medical histories and International Classification of Diseases, Ninth Revision (ICD-9) codes for 3375 participants from the Cardiovascular Health Study. Dementia, including Alzheimer's disease (AD) and vascular dementia (VaD), was classified using standardized research criteria.</p><p><b>RESULTS: </b>Cataracts were associated with AD (hazard ratio [HR] = 1.34; 95% confidence interval [CI] = 1.01-1.80) and VaD/mixed dementia (HR = 1.41; 95% CI = 1.02-1.95). AMD was associated with AD only (HR = 1.87; 95% CI = 1.13-3.09), whereas DR was associated with VaD/mixed dementia only (HR = 2.63; 95% CI = 1.10-6.27).</p><p><b>DISCUSSION: </b>Differential associations between specific ophthalmic conditions and dementia subtypes may elucidate pathophysiologic pathways. Lack of association between glaucoma and dementia was most surprising from these analyses.</p> |
| DOI | 10.1002/alz.12313 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 33788406 |
| Grant List | HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States / NS / NINDS NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States R01AG15928 / AG / NIA NIH HHS / United States |
ePub date:
21/03