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The Association of Lipids and Lipoproteins with Hip Fracture Risk the Cardiovascular Health Study.
Wednesday,2022-07-20 16:26 America/Los_Angeles — ecterry
| Title | The Association of Lipids and Lipoproteins with Hip Fracture Risk the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Barzilay, JI, Bůzková, P, Kuller, LH, Cauley, JA, Fink, HA, Sheets, K, Robbins, JA, Carbone, LD, Elam, RE, Mukamal, KJ |
| Journal | Am J Med |
| Date Published | 2022 Jun 06 |
| ISSN | 1555-7162 |
| Abstract | <p><b>BACKGROUND: </b>It is uncertain if lipids or lipoproteins are associated with osteoporotic fractures. In this study, incident hip fracture risk according to conventional lipid levels and lipoprotein levels and sizes was examined.</p><p><b>METHODS: </b>We followed 5832 participants aged ≥65 years from the Cardiovascular Health Study for hip fracture for a mean of 13.5 (SD 5.7) years. Standard enzymatic methods were used to determine lipid levels (HDL-c, LDL-c, triglycerides). Nuclear magnetic resonance spectroscopy was used to measure lipoprotein fractions (VLDL-P, LDL-P, HDL-P) in a subset of 1849 participants.</p><p><b>RESULTS: </b>We documented 755 incident hip fractures among women (1.19 fractures per 100 participant years [95% CI, 1.04, 1.35]) and 197 among men (0.67 fractures per 100 participant years [95% CI, 0.41, 1.10]) over an average follow-up. HDL-c and LDL-c levels had statistically significant non-linear U-shaped relationships with hip fracture risk (HDL-c, p=0.009; LDL-c, p=0.02). Triglyceride levels were not significantly associated with hip fracture risk. In fully adjusted conjoint models, higher VLDL-P concentration [HR per 1-standard (SD) increment 1.47 (1.13, 1.91)] and size [HR per 1-SD increment 1.24 [1.05, 1.46]) and higher HDL-P size (HR per 1-SD increment 1.81 [1.25, 2.62]) were all associated with higher hip fracture risk.</p><p><b>CONCLUSIONS: </b>Lipids and lipoproteins are associated with hip fracture risk in older adults. The associations are complex. Mechanistic studies are needed to understand these findings.</p> |
| DOI | 10.1016/j.amjmed.2022.05.024 |
| Alternate Journal | Am J Med |
| PubMed ID | 35679877 |
ePub date:
22/06