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Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts.
Wednesday,2023-08-23 11:17 America/Los_Angeles — ecterry
| Title | Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Ong, KLeung, Marklund, M, Huang, L, Rye, K-A, Hui, N, Pan, X-F, Rebholz, CM, Kim, H, Steffen, LM, van Westing, AC, Geleijnse, JM, Hoogeveen, EK, Chen, Y-Y, Chien, K-L, Fretts, AM, Lemaitre, RN, Imamura, F, Forouhi, NG, Wareham, NJ, Birukov, A, Jäger, S, Kuxhaus, O, Schulze, MB, de Mello, VDerenji, Tuomilehto, J, Uusitupa, M, Lindström, J, Tintle, N, Harris, WS, Yamasaki, K, Hirakawa, Y, Ninomiya, T, Tanaka, T, Ferrucci, L, Bandinelli, S, Virtanen, JK, Voutilainen, A, Jayasena, T, Thalamuthu, A, Poljak, A, Bustamante, S, Sachdev, PS, Senn, MK, Rich, SS, Tsai, MY, Wood, AC, Laakso, M, Lankinen, M, Yang, X, Sun, L, Li, H, Lin, X, Nowak, C, Arnlöv, J, Riserus, U, Lind, L, Le Goff, M, Samieri, C, Helmer, C, Qian, F, Micha, R, Tin, A, Köttgen, A, de Boer, IH, Siscovick, DS, Mozaffarian, D, Wu, JHY |
| Journal | BMJ |
| Volume | 380 |
| Pagination | e072909 |
| Date Published | 2023 Jan 18 |
| ISSN | 1756-1833 |
| Keywords | alpha-Linolenic Acid, Fatty Acids, Omega-3, Fatty Acids, Unsaturated, Humans, Middle Aged, Prospective Studies, Renal Insufficiency, Chronic, Risk Factors |
| Abstract | <p><b>OBJECTIVE: </b>To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived α linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD).</p><p><b>DESIGN: </b>Pooled analysis.</p><p><b>DATA SOURCES: </b>A consortium of 19 studies from 12 countries identified up to May 2020.</p><p><b>STUDY SELECTION: </b>Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate.</p><p><b>DATA EXTRACTION AND SYNTHESIS: </b>Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using inverse variance weighted meta-analysis.</p><p><b>MAIN OUTCOME MEASURES: </b>Primary outcome of incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m. In a sensitivity analysis, incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m and <75% of baseline rate.</p><p><b>RESULTS: </b>25 570 participants were included in the primary outcome analysis and 4944 (19.3%) developed incident CKD during follow-up (weighted median 11.3 years). In multivariable adjusted models, higher levels of total seafood n-3 PUFAs were associated with a lower incident CKD risk (relative risk per interquintile range 0.92, 95% confidence interval 0.86 to 0.98; P=0.009, I=9.9%). In categorical analyses, participants with total seafood n-3 PUFA level in the highest fifth had 13% lower risk of incident CKD compared with those in the lowest fifth (0.87, 0.80 to 0.96; P=0.005, I=0.0%). Plant derived α linolenic acid levels were not associated with incident CKD (1.00, 0.94 to 1.06; P=0.94, I=5.8%). Similar results were obtained in the sensitivity analysis. The association appeared consistent across subgroups by age (≥60 <60 years), estimated glomerular filtration rate (60-89 ≥90 mL/min/1.73 m), hypertension, diabetes, and coronary heart disease at baseline.</p><p><b>CONCLUSIONS: </b>Higher seafood derived n-3 PUFA levels were associated with lower risk of incident CKD, although this association was not found for plant derived n-3 PUFAs. These results support a favourable role for seafood derived n-3 PUFAs in preventing CKD.</p> |
| DOI | 10.1136/bmj-2022-072909 |
| Alternate Journal | BMJ |
| PubMed ID | 37587153 |
| PubMed Central ID | PMC10432561 |
ePub date:
23/01