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{Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
Tuesday,2023-10-10 12:35 America/Los_Angeles — ecterry
| Title | {Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease? |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Mantyh, WG, Cochran, JN, Taylor, JW, Broce, IJ, Geier, EG, Bonham, LW, Anderson, AG, Sirkis, DW, Joie, R, Iaccarino, L, Chaudhary, K, Edwards, L, Strom, A, Grant, H, Allen, IE, Miller, ZA, Gorno-Tempini, ML, Kramer, JH, Miller, BL, Desikan, RS, Rabinovici, GD, Yokoyama, JS |
| Journal | Alzheimers Dement (Amst) |
| Volume | 15 |
| Pagination | e12482 |
| Abstract | There is a unique genetic architecture of early- versus late-onset Alzheimer's disease (AD).Late-onset AD polygenic risk is not an explanation for early-onset AD.Polygenic risk of late-onset AD does not predict early-onset AD biology.Unique genetic architecture of early- versus late-onset AD parallels AD heterogeneity. |
ePub date:
23/09