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Depressive symptoms and age-related macular degeneration in older people: the cardiovascular health study.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Depressive symptoms and age-related macular degeneration in older people: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Sun, C, Tikellis, G, Klein, R, Steffens, DC, Larsen, EKMarino, Wong, TY |
| Journal | Ophthalmic Epidemiol |
| Volume | 14 |
| Issue | 3 |
| Pagination | 127-33 |
| Date Published | 2007 May-Jun |
| ISSN | 0928-6586 |
| Keywords | Aged, Aged, 80 and over, Cardiovascular Diseases, Cross-Sectional Studies, Depressive Disorder, Female, Health Surveys, Humans, Intelligence Tests, Macular Degeneration, Male, Photography, United States |
| Abstract | <p><b>PURPOSE: </b>To examine the association between age-related macular degeneration (AMD) and depressive symptoms.</p><p><b>METHODS: </b>Population-based, cross-sectional study. A total of 2,194 persons aged 69-97 years were included in the current analyses. During the 1997-1998 examination, retinal photography from one randomly selected eye was graded for presence of early and late AMD using a modified Wisconsin AMD by Grading System. Depressive symptoms were assessed via a modified version of the Centers for Epidemiologic Studies Depression (CES-D) scale annually from 1989 through 1997-1998. Depressive symptoms were defined as a CES-D score of >9 (top quartile of CES-D score) at the 1997-1998 examination.</p><p><b>RESULTS: </b>There were 338 (15.6%) individuals with early AMD and 29 (1.3%) with late AMD. Among them, 368 (16.8%) persons had depressive symptoms at the 1997-1998 examination. Depressive symptoms were not associated with early AMD (multivariable adjusted odds ratio [OR]: 0.97; 95% confidence intervals [CI]: 0.69-1.36) or late AMD (OR: 1.15; 95% CI: 0.38-3.46). Including persons using anti-depressive medications did not alter these associations (OR: 0.98; 95% CI: 0.74-1.32 for early AMD and OR: 0.97; 95% CI: 0.35-2.67 for late AMD). There was no association in multinomial logistic regression models of increasing quartiles of the CES-D scores with early or late AMD status.</p><p><b>CONCLUSIONS: </b>Our study did not find an association between early AMD and depressive symptoms in older people.</p> |
| DOI | 10.1080/09286580601186742 |
| Alternate Journal | Ophthalmic Epidemiol |
| PubMed ID | 17613847 |
| Grant List | N01-HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R21-HL077166 / HL / NHLBI NIH HHS / United States |