You are here
A plasma protein-based risk score to predict hip fractures.
Thursday,2024-07-11 09:51 America/Los_Angeles — ecterry
| Title | A plasma protein-based risk score to predict hip fractures. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Austin, TR, Nethander, M, Fink, HA, Törnqvist, AE, Jalal, DI, Bůzková, P, Barzilay, JI, Carbone, L, Gabrielsen, ME, Grahnemo, L, Lu, T, Hveem, K, Jonasson, C, Kizer, JR, Langhammer, A, Mukamal, KJ, Gerszten, RE, Psaty, BM, Robbins, JA, Sun, YV, Skogholt, AHeidi, Kanis, JA, Johansson, H, Åsvold, BOlav, Valderrábano, RJ, Zheng, J, J Richards, B, Coward, E, Ohlsson, C |
| Journal | Nat Aging |
| Date Published | 2024 May 27 |
| ISSN | 2662-8465 |
| Abstract | <p>As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Trøndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined.</p> |
| DOI | 10.1038/s43587-024-00639-7 |
| Alternate Journal | Nat Aging |
| PubMed ID | 38802582 |
| PubMed Central ID | 7573502 |
| Grant List | U01HL130114 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) / N01HC85083 / HL / NHLBI NIH HHS / United States R01HL144483 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) / U01HL080295 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) / KAW 2015.0317 / / Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) / R01 HL144483 / HL / NHLBI NIH HHS / United States LU2021-0096 / / IngaBritt och Arne Lundbergs Forskningsstiftelse (Ingabritt and Arne Lundberg Research Foundation) / 2020-01392 / / Vetenskapsrådet (Swedish Research Council) / N01HC85083 / HL / NHLBI NIH HHS / United States |
ePub date:
24/05