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Trimethylamine -Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community-Based Populations.
Tuesday,2024-09-17 13:33 America/Los_Angeles — ecterry
| Title | Trimethylamine -Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community-Based Populations. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Tang, WHWilson, Lemaitre, RN, Jensen, PN, Wang, M, Wang, Z, Li, XS, Nemet, I, Lee, Y, Lai, HTM, Otto, MC de Olive, Fretts, AM, Sotoodehnia, N, DiDonato, JA, Bäckhed, F, Psaty, BM, Siscovick, DS, Budoff, MJ, Mozaffarian, D, Hazen, SL |
| Journal | Circ Heart Fail |
| Volume | 17 |
| Issue | 8 |
| Pagination | e011569 |
| Date Published | 2024 Aug |
| ISSN | 1941-3297 |
| Keywords | Aged, Aged, 80 and over, Betaine, Biomarkers, Carnitine, Choline, Female, Gastrointestinal Microbiome, Heart Failure, Humans, Incidence, Male, Methylamines, Middle Aged, Risk Factors, United States |
| Abstract | <p><b>BACKGROUND: </b>Growing evidence indicates that trimethylamine -oxide, a gut microbial metabolite of dietary choline and carnitine, promotes both cardiovascular disease and chronic kidney disease risk. It remains unclear how circulating concentrations of trimethylamine -oxide and its related dietary and gut microbe-derived metabolites (choline, betaine, carnitine, γ-butyrobetaine, and crotonobetaine) affect incident heart failure (HF).</p><p><b>METHODS: </b>We evaluated 11 768 participants from the Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis with serial measures of metabolites. Cox proportional hazard models were used to examine the associations between metabolites and incident HF, adjusted for cardiovascular disease risk factors.</p><p><b>RESULTS: </b>In all, 2102 cases of HF occurred over a median follow-up of 15.9 years. After adjusting for traditional risk factors, higher concentrations of trimethylamine -oxide (hazard ratio, 1.15 [95% CI, 1.09-1.20]; <0.001), choline (hazard ratio, 1.44 [95% CI, 1.26-1.64]; <0.001), and crotonobetaine (hazard ratio, 1.24 [95% CI, 1.16-1.32]; <0.001) were associated with increased risk for incident HF. After further adjustment for renal function (potential confounder or mediator), these associations did not reach Bonferroni-corrected statistical significance (=0.01, 0.049, and 0.006, respectively). Betaine and carnitine were nominally associated with a higher incidence of HF (<0.05). In exploratory analyses, results were similar for subtypes of HF based on left ventricular ejection fraction, and associations appeared generally stronger among Black and Hispanic/Latino versus White adults, although there were no interactions for any metabolites with race.</p><p><b>CONCLUSIONS: </b>In this pooled analysis of 2 well-phenotyped, diverse, community-based cohorts, circulating concentrations of gut microbe-derived metabolites such as trimethylamine -oxide, choline, and crotonobetaine were independently associated with a higher risk of developing HF.</p><p><b>REGISTRATION: </b>URL: https://www.clinicaltrials.gov/; Unique identifiers: NCT00005133 and NCT00005487.</p> |
| DOI | 10.1161/CIRCHEARTFAILURE.124.011569 |
| Alternate Journal | Circ Heart Fail |
| PubMed ID | 39119698 |
| PubMed Central ID | PMC11335438 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States R01 HL103866 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL135920 / HL / NHLBI NIH HHS / United States R01 HL167831 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States P01 HL147823 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |
ePub date:
24/08