You are here
Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype.
Tuesday,2025-02-11 14:44 America/Los_Angeles — ecterry
| Title | Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Nagarajan, P, Kurniansyah, N, Lee, J, Gharib, SA, Xu, Y, Zhang, Y, Spitzer, B, Faquih, T, Zhou, H, Boerwinkle, E, Chen, H, Gottlieb, DJ, Guo, X, Heard-Costa, NL, Hidalgo, BA, Levy, D, Liu, PY, Mei, H, Montalvan, R, Mukherjee, S, North, KE, O'Conner, GT, Palmer, LJ, Patel, SR, Psaty, BM, Purcell, SM, Raffield, LM, Rich, SS, Rotter, JI, Saxena, R, Smith, AV, Stone, KL, Zhu, X, Cade, BE, Sofer, T, Redline, S, Wang, H |
| Corporate/Institutional Authors | TOPMed Sleep Trait WG |
| Journal | medRxiv |
| Date Published | 2024 Oct 28 |
| Abstract | <p>Obstructive sleep apnea (OSA) is a multifactorial sleep disorder characterized by a strong genetic basis. Excessive daytime sleepiness (EDS) is a symptom that is reported by a subset of OSA patients, persisting even after treatment with continuous positive airway pressure (CPAP). It is recognized as a clinical subtype underlying OSA carrying alarming heightened cardiovascular risk. Thus, conceptualizing EDS as an exposure variable, we sought to investigate EDS's influence on genetic variation linked to apnea-hypopnea index (AHI), a diagnostic measure of OSA severity. This study serves as the first large-scale genome-wide gene x environment interaction analysis for AHI, investigating the interplay between its genetic markers and EDS across and within specific sex. Our work pools together whole genome sequencing data from seven cohorts, enabling a diverse dataset (four population backgrounds) of over 11,500 samples. Among the total 16 discovered genetic targets with interaction evidence with EDS, eight are previously unreported for OSA, including , , and identified in all sexes; , , and identified in males; and and identified in females. We discuss connections to insulin resistance, thiamine deficiency, and resveratrol use that may be worthy of therapeutic consideration for excessively sleepy OSA patients.</p> |
| DOI | 10.1101/2024.10.25.24316158 |
| Alternate Journal | medRxiv |
| PubMed ID | 39574859 |
| PubMed Central ID | PMC11581070 |
| Grant List | U01 AG042139 / AG / NIA NIH HHS / United States HHSN268201100037C / HL / NHLBI NIH HHS / United States UL1 RR033176 / RR / NCRR NIH HHS / United States R01 HL103612 / HL / NHLBI NIH HHS / United States HHSN268201300005C / HL / NHLBI NIH HHS / United States HHSN268201500003C / HL / NHLBI NIH HHS / United States HHSN268201800012C / HL / NHLBI NIH HHS / United States HHSN268201300004C / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States R01 HL071251 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States R01 HL070848 / HL / NHLBI NIH HHS / United States R01 HL046380 / HL / NHLBI NIH HHS / United States U54 HG003067 / HG / NHGRI NIH HHS / United States HHSN268201300001C / HL / NHLBI NIH HHS / United States R01 HL071259 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States HHSN268201300003I / HL / NHLBI NIH HHS / United States 75N92022D00002 / HL / NHLBI NIH HHS / United States R01 HL071194 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States R01 HL070847 / HL / NHLBI NIH HHS / United States HHSN268201800014I / HB / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States UL1 TR000128 / TR / NCATS NIH HHS / United States R01 HL092577 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States R01 HL085251 / HL / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States U01 HL120393 / HL / NHLBI NIH HHS / United States R01 HL113338 / HL / NHLBI NIH HHS / United States R01 HL071250 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States N01HC65236 / HL / NHLBI NIH HHS / United States R01 HL070842 / HL / NHLBI NIH HHS / United States U01 AG042124 / AG / NIA NIH HHS / United States N01HC65235 / HL / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States U01 AG042145 / AG / NIA NIH HHS / United States HHSN268201800014C / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC65234 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States 75N92022D00004 / HL / NHLBI NIH HHS / United States R35 HL135818 / HL / NHLBI NIH HHS / United States R01 HL098433 / HL / NHLBI NIH HHS / United States N01HC65233 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States R01 HL071051 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268201800013I / MD / NIMHD NIH HHS / United States HHSN268201500015C / HL / NHLBI NIH HHS / United States N01HC65237 / HL / NHLBI NIH HHS / United States U01 AG042168 / AG / NIA NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States HHSN268201800012I / HL / NHLBI NIH HHS / United States R01 HL070841 / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States U01 AG042140 / AG / NIA NIH HHS / United States R01 HL070838 / HL / NHLBI NIH HHS / United States HHSN268201800011C / HL / NHLBI NIH HHS / United States KL2 RR024990 / RR / NCRR NIH HHS / United States HHSN268201300003C / HL / NHLBI NIH HHS / United States 75N92022D00003 / HL / NHLBI NIH HHS / United States HHSN268201500003I / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States 75N92022D00005 / HL / NHLBI NIH HHS / United States R01 AR051124 / AR / NIAMS NIH HHS / United States R01 HL070839 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States HHSN268201800015I / HB / NHLBI NIH HHS / United States R01 HL071205 / HL / NHLBI NIH HHS / United States 75N92019D00031 / HL / NHLBI NIH HHS / United States RC2 AR058973 / AR / NIAMS NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States U01 AG027810 / AG / NIA NIH HHS / United States HHSN268201800010I / HB / NHLBI NIH HHS / United States UM1 HG008898 / HG / NHGRI NIH HHS / United States R01 HL117626 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States UL1 TR001881 / TR / NCATS NIH HHS / United States HHSN268201800011I / HB / NHLBI NIH HHS / United States R01 HL153814 / HL / NHLBI NIH HHS / United States U24 HG008956 / HG / NHGRI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States 75N92022D00001 / HL / NHLBI NIH HHS / United States R01 HL071258 / HL / NHLBI NIH HHS / United States U01 AG042143 / AG / NIA NIH HHS / United States HHSN268201600033C / HL / NHLBI NIH HHS / United States R01 HL070837 / HL / NHLBI NIH HHS / United States U01 AR066160 / AR / NIAMS NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |
ePub date:
24/10