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... (TGF-β1) serves several important roles in bone formation and resorption. A consequence of TGF-β1 activation is ... levels. Methods: Participants were from the Cardiovascular Health Study (mean age 78 years; mean follow-up 8.3 years). ... of TGF-B action, secretion, and function can result in bone disease. This has been demonstrated in several rodent ...- 2014-07-28 09:27 - 1 comment
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... eGFR in the slope determination (current eGFR). Setting and population: Up to 1.7 million subjects from 35 cohorts (22 general population and high cardiovascular risk cohorts and 13 chronic kidney disease [CKD] cohorts) within the CKD Progression ...- 2014-11-11 09:25
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... words) 30 31 Background Myocardial infarction (MI), stroke, and diabetes mellitus have been studied 32 separately as risk factors for adverse health outcomes. However, the consequences of having two 33 ... person-years of follow-up, we calculated hazard ratios and 37 incidence rates, for cardiovascular events (n=47,436) ...- 2014-05-19 11:05
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... at lower estimated glomerular filtration rate (eGFR) and higher albuminuria (albumin to creatinine ratio, ACR). The additional risk associated with age, sex, and race has not been quantified across the full range of ... in general population cohorts; 79,519 in chronic kidney disease cohorts) from 14 cohorts in 8 countries, we ...- 2014-03-12 10:43
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The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. We conducted a genomewide ...- 2014-02-25 10:21
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... Associations between soluble IL-2Rα (sIL-2Rα) and cardiovascular disease (CVD) have not been widely studied and little is ... 766 African-American (AA) adults from the Cardiovascular Health Study (CHS) and examined associations with baseline ...- 2014-08-13 08:12 - 1 comment
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... for nicotine dependence in European Americans (MAF=0.35), and contributes to risk in African Americans (MAF=0.06). To ... risk. These newly identified variants may have important health implications by influencing risk for smoking-related diseases and response to cessation therapies. Genetics ...- 2014-11-03 13:12 - 1 comment
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Association Between 6-Minute Walk Test and All-Cause Mortality, Coronary Heart Disease-Specific Mortality, and Incident Coronary Heart Disease. ...- 2014-05-05 13:57
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Testosterone, dihydrotestosterone, and incident cardiovascular disease and mortality in the cardiovascular health study. ...- 2014-03-31 12:01
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... robust predictor of risk for progression to end-stage renal disease (ESRD). It is unclear how much prognostic ... all eGFR values in a 3-year baseline period within 13 CKD and 9 general population or high-risk cohorts. We modeled ... subsequent ESRD as a spline function of eGFR slopes overall and in subgroups with different eGFR levels, adjusting for ...- 2014-10-23 13:36