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Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study.
Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
| Title | Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Gottlieb, DJ, Yenokyan, G, Newman, AB, O'Connor, GT, Punjabi, NM, Quan, SF, Redline, S, Resnick, HE, Tong, EK, Diener-West, M, Shahar, E |
| Journal | Circulation |
| Volume | 122 |
| Issue | 4 |
| Pagination | 352-60 |
| Date Published | 2010 Jul 27 |
| ISSN | 1524-4539 |
| Keywords | Adult, Aged, Coronary Disease, Female, Heart Failure, Humans, Longitudinal Studies, Male, Middle Aged, Polysomnography, Proportional Hazards Models, Prospective Studies, Sleep Apnea, Obstructive, Survival Analysis |
| Abstract | <p><b>BACKGROUND: </b>Clinic-based observational studies in men have reported that obstructive sleep apnea is associated with an increased incidence of coronary heart disease. The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women.</p><p><b>METHODS AND RESULTS: </b>A total of 1927 men and 2495 women > or =40 years of age and free of coronary heart disease and heart failure at the time of baseline polysomnography were followed up for a median of 8.7 years in this prospective longitudinal epidemiological study. After adjustment for multiple risk factors, obstructive sleep apnea was a significant predictor of incident coronary heart disease (myocardial infarction, revascularization procedure, or coronary heart disease death) only in men < or =70 years of age (adjusted hazard ratio 1.10 [95% confidence interval 1.00 to 1.21] per 10-unit increase in apnea-hypopnea index [AHI]) but not in older men or in women of any age. Among men 40 to 70 years old, those with AHI > or =30 were 68% more likely to develop coronary heart disease than those with AHI <5. Obstructive sleep apnea predicted incident heart failure in men but not in women (adjusted hazard ratio 1.13 [95% confidence interval 1.02 to 1.26] per 10-unit increase in AHI). Men with AHI > or =30 were 58% more likely to develop heart failure than those with AHI <5.</p><p><b>CONCLUSIONS: </b>Obstructive sleep apnea is associated with an increased risk of incident heart failure in community-dwelling middle-aged and older men; its association with incident coronary heart disease in this sample is equivocal.</p> |
| DOI | 10.1161/CIRCULATIONAHA.109.901801 |
| Alternate Journal | Circulation |
| PubMed ID | 20625114 |
| PubMed Central ID | PMC3117288 |
| Grant List | U01HL53937 / HL / NHLBI NIH HHS / United States U01 HL053916 / HL / NHLBI NIH HHS / United States U01HL64360 / HL / NHLBI NIH HHS / United States U01 HL063463 / HL / NHLBI NIH HHS / United States U01HL53938 / HL / NHLBI NIH HHS / United States U01 HL053938 / HL / NHLBI NIH HHS / United States U01HL53934 / HL / NHLBI NIH HHS / United States U01 HL064360 / HL / NHLBI NIH HHS / United States U01 HL053941 / HL / NHLBI NIH HHS / United States U01HL63429 / HL / NHLBI NIH HHS / United States U01HL53931 / HL / NHLBI NIH HHS / United States U01HL53941 / HL / NHLBI NIH HHS / United States U01 HL053934 / HL / NHLBI NIH HHS / United States U01 HL063429 / HL / NHLBI NIH HHS / United States U01 HL053941-06 / HL / NHLBI NIH HHS / United States U01 HL053937 / HL / NHLBI NIH HHS / United States U01HL53940 / HL / NHLBI NIH HHS / United States U01HL63463 / HL / NHLBI NIH HHS / United States U01 HL053931 / HL / NHLBI NIH HHS / United States |