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Discovery and refinement of loci associated with lipid levels.

TitleDiscovery and refinement of loci associated with lipid levels.
Publication TypeJournal Article
Year of Publication2013
AuthorsWiller, CJ, Schmidt, EM, Sengupta, S, Peloso, GM, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, ML, Mora, S, Beckmann, JS, Bragg-Gresham, JL, Chang, H-Y, Demirkan, A, Hertog, HMDen, Do, R, Donnelly, LA, Ehret, GB, Esko, T, Feitosa, MF, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, RM, Freitag, DF, Gurdasani, D, Heikkilä, K, Hyppönen, E, Isaacs, A, Jackson, AU, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, ME, Li, X, Luan, J'an, Lyytikäinen, L-P, Magnusson, PKE, Mangino, M, Mihailov, E, Montasser, ME, Müller-Nurasyid, M, Nolte, IM, O'Connell, JR, Palmer, CD, Perola, M, Petersen, A-K, Sanna, S, Saxena, R, Service, SK, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, RJ, Surakka, I, Tanaka, T, Teslovich, TM, Thorleifsson, G, van den Herik, EG, Voight, BF, Volcik, KA, Waite, LL, Wong, A, Wu, Y, Zhang, W, Absher, D, Asiki, G, Barroso, I, Been, LF, Bolton, JL, Bonnycastle, LL, Brambilla, P, Burnett, MS, Cesana, G, Dimitriou, M, Doney, ASF, Döring, A, Elliott, P, Epstein, SE, Eyjolfsson, GIngi, Gigante, B, Goodarzi, MO, Grallert, H, Gravito, ML, Groves, CJ, Hallmans, G, Hartikainen, A-L, Hayward, C, Hernandez, D, Hicks, AA, Holm, H, Hung, Y-J, Illig, T, Jones, MR, Kaleebu, P, Kastelein, JJP, Khaw, K-T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimäki, T, Lin, S-Y, Lindström, J, Loos, RJF, Mach, F, McArdle, WL, Meisinger, C, Mitchell, BD, Müller, G, Nagaraja, R, Narisu, N, Nieminen, TVM, Nsubuga, RN, Olafsson, I, Ong, KK, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, DJ, Reilly, MP, Ridker, PM, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stančáková, A, Stirrups, K, Swift, AJ, Tiret, L, Uitterlinden, AG, L van Pelt, J, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, SH, Willemsen, G, Wilsgaard, T, Wilson, JF, Young, EH, Zhao, JH, Adair, LS, Arveiler, D, Assimes, TL, Bandinelli, S, Bennett, F, Bochud, M, Boehm, BO, Boomsma, DI, Borecki, IB, Bornstein, SR, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, JC, Chen, Y-DI, Collins, FS, Cooper, RS, Danesh, J, Dedoussis, G, de Faire, U, Feranil, AB, Ferrieres, J, Ferrucci, L, Freimer, NB, Gieger, C, Groop, LC, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, TB, Hingorani, A, Hirschhorn, JN, Hofman, A, G Hovingh, K, Hsiung, CAgnes, Humphries, SE, Hunt, SC, Hveem, K, Iribarren, C, Jarvelin, M-R, Jula, A, Kähönen, M, Kaprio, J, Kesäniemi, A, Kivimaki, M, Kooner, JS, Koudstaal, PJ, Krauss, RM, Kuh, D, Kuusisto, J, Kyvik, KO, Laakso, M, Lakka, TA, Lind, L, Lindgren, CM, Martin, NG, März, W, McCarthy, MI, McKenzie, CA, Meneton, P, Metspalu, A, Moilanen, L, Morris, AD, Munroe, PB, Njølstad, I, Pedersen, NL, Power, C, Pramstaller, PP, Price, JF, Psaty, BM, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, DK, Saramies, J, Schwarz, PEH, Sheu, WH-H, Shuldiner, AR, Siegbahn, A, Spector, TD, Stefansson, K, Strachan, DP, Tayo, BO, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, CM, Vollenweider, P, Wallentin, L, Wareham, NJ, Whitfield, JB, Wolffenbuttel, BHR, Ordovas, JM, Boerwinkle, E, Palmer, CNA, Thorsteinsdottir, U, Chasman, DI, Rotter, JI, Franks, PW, Ripatti, S, Cupples, AL, Sandhu, MS, Rich, SS, Boehnke, M, Deloukas, P, Kathiresan, S, Mohlke, KL, Ingelsson, E, Abecasis, GR
Corporate/Institutional AuthorsGlobal Lipids Genetics Consortium
JournalNat Genet
Volume45
Issue11
Pagination1274-1283
Date Published2013 Nov
ISSN1546-1718
KeywordsAfrican Continental Ancestry Group, Asian Continental Ancestry Group, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, European Continental Ancestry Group, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Lipids, Triglycerides
Abstract<p>Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.</p>
DOI10.1038/ng.2797
Alternate JournalNat. Genet.
PubMed ID24097068
PubMed Central IDPMC3838666
Grant ListCZB/4/710 / / Chief Scientist Office / United Kingdom
CZB/4/672 / / Chief Scientist Office / United Kingdom
RG/08/008/25291 / / British Heart Foundation / United Kingdom
R01 HL109946 / HL / NHLBI NIH HHS / United States
RG/08/014/24067 / / British Heart Foundation / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
MC_U950080926 / / Medical Research Council / United Kingdom
G1000143 / / Medical Research Council / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
MR/L003120/1 / / Medical Research Council / United Kingdom
R01 HL105756 / HL / NHLBI NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
MC_U123092720 / / Medical Research Council / United Kingdom
MC_U106179472 / / Medical Research Council / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
G0901213 / / Medical Research Council / United Kingdom
100891 / / Wellcome Trust / United Kingdom
090532 / / Wellcome Trust / United Kingdom
R00 HL094535 / HL / NHLBI NIH HHS / United States
MR/K013351/1 / / Medical Research Council / United Kingdom
PG/08/094/26019 / / British Heart Foundation / United Kingdom
P30 DK020572 / DK / NIDDK NIH HHS / United States
G0801566 / / Medical Research Council / United Kingdom
MC_U106188470 / / Medical Research Council / United Kingdom
U01 HL069757 / HL / NHLBI NIH HHS / United States