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Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults : the Cardiovascular Health Study.
Tuesday,2012-11-06 12:04 America/Los_Angeles — eenright
| Title | Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults : the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Siscovick, DS, Schwartz, SM, Corey, L, Grayston, JT, Ashley, R, Wang, SP, Psaty, BM, Tracy, RP, Kuller, LH, Kronmal, RA |
| Journal | Circulation |
| Volume | 102 |
| Issue | 19 |
| Pagination | 2335-40 |
| Date Published | 2000 Nov 07 |
| ISSN | 1524-4539 |
| Keywords | Adult, Age Factors, Aged, Antibodies, Bacterial, Antibodies, Viral, Case-Control Studies, Chlamydophila pneumoniae, Coronary Disease, Cytomegalovirus, Female, Herpesvirus 1, Human, HIV Antibodies, Humans, Immunoglobulin G, Male, Myocardial Infarction, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>Whether serological evidence of prior infection with Chlamydia pneumoniae, herpes simplex virus type 1 (HSV-1), and cytomegalovirus (CMV) is associated with myocardial infarction (MI) and coronary heart disease (CHD) death remains a source of controversy.</p><p><b>METHODS AND RESULTS: </b>We conducted a nested case-control study among participants in the Cardiovascular Health Study, a cohort study of persons aged >/=65 years. Cases experienced an incident MI and CHD death (n=213). Control subjects were matched to cases by age, sex, clinic, year of enrollment, and month of blood draw (n=405). Serum was analyzed for IgG antibodies to C pneumoniae, HSV-1, and CMV. After adjustment for other risk factors, the risk of MI and CHD death was associated with the presence of IgG antibodies to HSV-1 (odds ratio [OR] 2.0, 95% CI 1.1 to 3.6) but was not associated with the presence of IgG antibodies to either C pneumoniae (OR 1.1, 95% CI 0.7 to 1.8) or CMV (OR 1.2, 95% CI 0.7 to 1.9). Although there was little association with low to moderate C pneumoniae antibody titers (</=1:512), high-titer (1:1024) C pneumoniae antibody was associated with an increased risk (OR 2.2, 95% CI 1.1 to 4.4).</p><p><b>CONCLUSIONS: </b>Among older adults, the presence of IgG antibodies to HSV-1 was associated with a 2-fold increase in the risk of incident MI and CHD death. For C pneumoniae, only high-titer IgG antibodies were associated with an increased risk of MI and CHD death. The presence of IgG antibodies to CMV was not associated with risk among the elderly.</p> |
| DOI | 10.1161/01.cir.102.19.2335 |
| Alternate Journal | Circulation |
| PubMed ID | 11067785 |
| Grant List | N01-HC-87079 / HC / NHLBI NIH HHS / United States N01-HC-87080 / HC / NHLBI NIH HHS / United States R55-HL-46900 / HL / NHLBI NIH HHS / United States |