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Common variants associated with plasma triglycerides and risk for coronary artery disease.
Monday,2019-04-22 17:11 America/Los_Angeles — ecterry
| Title | Common variants associated with plasma triglycerides and risk for coronary artery disease. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Do, R, Willer, CJ, Schmidt, EM, Sengupta, S, Gao, C, Peloso, GM, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, ML, Mora, S, Beckmann, JS, Bragg-Gresham, JL, Chang, H-Y, Demirkan, A, Hertog, HMDen, Donnelly, LA, Ehret, GB, Esko, T, Feitosa, MF, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, RM, Freitag, DF, Gurdasani, D, Heikkilä, K, Hyppönen, E, Isaacs, A, Jackson, AU, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, ME, Li, X, Luan, J'an, Lyytikäinen, L-P, Magnusson, PKE, Mangino, M, Mihailov, E, Montasser, ME, Müller-Nurasyid, M, Nolte, IM, O'Connell, JR, Palmer, CD, Perola, M, Petersen, A-K, Sanna, S, Saxena, R, Service, SK, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, RJ, Surakka, I, Tanaka, T, Teslovich, TM, Thorleifsson, G, van den Herik, EG, Voight, BF, Volcik, KA, Waite, LL, Wong, A, Wu, Y, Zhang, W, Absher, D, Asiki, G, Barroso, I, Been, LF, Bolton, JL, Bonnycastle, LL, Brambilla, P, Burnett, MS, Cesana, G, Dimitriou, M, Doney, ASF, Döring, A, Elliott, P, Epstein, SE, Eyjolfsson, GIngi, Gigante, B, Goodarzi, MO, Grallert, H, Gravito, ML, Groves, CJ, Hallmans, G, Hartikainen, A-L, Hayward, C, Hernandez, D, Hicks, AA, Holm, H, Hung, Y-J, Illig, T, Jones, MR, Kaleebu, P, Kastelein, JJP, Khaw, K-T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimäki, T, Lin, S-Y, Lindström, J, Loos, RJF, Mach, F, McArdle, WL, Meisinger, C, Mitchell, BD, Müller, G, Nagaraja, R, Narisu, N, Nieminen, TVM, Nsubuga, RN, Olafsson, I, Ong, KK, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, DJ, Reilly, MP, Ridker, PM, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stančáková, A, Stirrups, K, Swift, AJ, Tiret, L, Uitterlinden, AG, L van Pelt, J, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, SH, Willemsen, G, Wilsgaard, T, Wilson, JF, Young, EH, Zhao, JH, Adair, LS, Arveiler, D, Assimes, TL, Bandinelli, S, Bennett, F, Bochud, M, Boehm, BO, Boomsma, DI, Borecki, IB, Bornstein, SR, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, JC, Chen, Y-DI, Collins, FS, Cooper, RS, Danesh, J, Dedoussis, G, de Faire, U, Feranil, AB, Ferrieres, J, Ferrucci, L, Freimer, NB, Gieger, C, Groop, LC, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, TB, Hingorani, A, Hirschhorn, JN, Hofman, A, G Hovingh, K, Hsiung, CAgnes, Humphries, SE, Hunt, SC, Hveem, K, Iribarren, C, Jarvelin, M-R, Jula, A, Kähönen, M, Kaprio, J, Kesäniemi, A, Kivimaki, M, Kooner, JS, Koudstaal, PJ, Krauss, RM, Kuh, D, Kuusisto, J, Kyvik, KO, Laakso, M, Lakka, TA, Lind, L, Lindgren, CM, Martin, NG, März, W, McCarthy, MI, McKenzie, CA, Meneton, P, Metspalu, A, Moilanen, L, Morris, AD, Munroe, PB, Njølstad, I, Pedersen, NL, Power, C, Pramstaller, PP, Price, JF, Psaty, BM, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, DK, Saramies, J, Schwarz, PEH, Sheu, WH-H, Shuldiner, AR, Siegbahn, A, Spector, TD, Stefansson, K, Strachan, DP, Tayo, BO, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, CM, Vollenweider, P, Wallentin, L, Wareham, NJ, Whitfield, JB, Wolffenbuttel, BHR, Altshuler, D, Ordovas, JM, Boerwinkle, E, Palmer, CNA, Thorsteinsdottir, U, Chasman, DI, Rotter, JI, Franks, PW, Ripatti, S, Cupples, AL, Sandhu, MS, Rich, SS, Boehnke, M, Deloukas, P, Mohlke, KL, Ingelsson, E, Abecasis, GR, Daly, MJ, Neale, BM, Kathiresan, S |
| Journal | Nat Genet |
| Volume | 45 |
| Issue | 11 |
| Pagination | 1345-52 |
| Date Published | 2013 Nov |
| ISSN | 1546-1718 |
| Keywords | Biological Transport, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors, Triglycerides |
| Abstract | <p>Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD. </p> |
| DOI | 10.1038/ng.2795 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 24097064 |
| PubMed Central ID | PMC3904346 |
| Grant List | R01 DK093757 / DK / NIDDK NIH HHS / United States CZB/4/710 / / Chief Scientist Office / United Kingdom CZB/4/672 / / Chief Scientist Office / United Kingdom RG/08/008/25291 / / British Heart Foundation / United Kingdom R01 HL107816 / HL / NHLBI NIH HHS / United States R01 HL109946 / HL / NHLBI NIH HHS / United States R01HL107816 / HL / NHLBI NIH HHS / United States RG/08/014/24067 / / British Heart Foundation / United Kingdom R01 DK072193 / DK / NIDDK NIH HHS / United States MC_U950080926 / / Medical Research Council / United Kingdom G1000143 / / Medical Research Council / United Kingdom UL1 TR000124 / TR / NCATS NIH HHS / United States MR/L003120/1 / / Medical Research Council / United Kingdom R01 HL105756 / HL / NHLBI NIH HHS / United States T32 HL007208 / HL / NHLBI NIH HHS / United States MC_U106179471 / / Medical Research Council / United Kingdom P30 DK063491 / DK / NIDDK NIH HHS / United States / / Canadian Institutes of Health Research / Canada MC_U123092720 / / Medical Research Council / United Kingdom MC_U106179472 / / Medical Research Council / United Kingdom G0401527 / / Medical Research Council / United Kingdom G0701863 / / Medical Research Council / United Kingdom G0901213 / / Medical Research Council / United Kingdom 100891 / / Wellcome Trust / United Kingdom 090532 / / Wellcome Trust / United Kingdom MR/K013351/1 / / Medical Research Council / United Kingdom PG/08/094/26019 / / British Heart Foundation / United Kingdom T32HL007208 / HL / NHLBI NIH HHS / United States P30 DK020572 / DK / NIDDK NIH HHS / United States G0801566 / / Medical Research Council / United Kingdom MR/K013491/1 / / Medical Research Council / United Kingdom MC_U106188470 / / Medical Research Council / United Kingdom U01 HL069757 / HL / NHLBI NIH HHS / United States |
ePub date:
13/10