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Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Schellenbaum, GD, Smith, NL, Heckbert, SR, Lumley, T, Rea, TD, Furberg, CD, Lyles, MF, Psaty, BM |
| Journal | J Am Geriatr Soc |
| Volume | 53 |
| Issue | 11 |
| Pagination | 1996-2000 |
| Date Published | 2005 Nov |
| ISSN | 0002-8614 |
| Keywords | Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors, Female, Hand Strength, Heart Failure, Humans, Hypertension, Male, Multivariate Analysis, Outcome Assessment, Health Care, Prospective Studies, Statistics as Topic, United States, Weight Loss |
| Abstract | <p><b>OBJECTIVES: </b>To determine whether angiotensin-converting enzyme (ACE) inhibitor use may be associated with weight maintenance and sustained muscle strength (measured by grip strength) in older adults.</p><p><b>DESIGN: </b>Data from the Cardiovascular Health Study (CHS), a community-based prospective cohort study of 5,888 older adults, were used.</p><p><b>SETTING: </b>Subjects were recruited from four U.S. sites beginning in 1989; this analysis included data through 2001.</p><p><b>PARTICIPANTS: </b>CHS participants with congestive heart failure (CHF) or treated hypertension.</p><p><b>MEASUREMENTS: </b>The exposure, current ACE inhibitor use, was ascertained by medication inventory at annual clinic visits; the outcomes were weight change and grip-strength change during the following year. Multivariate linear regression was used, accounting for correlations between observations on the same participant over time.</p><p><b>RESULTS: </b>The average annual weight change was -0.38 kg in 2,834 participants (14,443 person-years) with treated hypertension and -0.62 kg in 342 participants (980 person-years) with CHF. ACE inhibitor use was associated with less annual weight loss after adjustment for potential confounders: a difference of 0.17 kg (95% confidence interval (CI)=0.05-0.29) in those with treated hypertension and 0.29 kg (95% CI=-0.25-0.83) in those with CHF. There was no evidence of association between ACE inhibitor use and grip-strength change.</p><p><b>CONCLUSION: </b>ACE inhibitor use may be associated with weight maintenance, but not maintenance of muscle strength, in older adults with treated hypertension.</p> |
| DOI | 10.1111/j.1532-5415.2005.53568.x |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 16274385 |
| Grant List | 1-T32-HL07902 / HL / NHLBI NIH HHS / United States AG09556 / AG / NIA NIH HHS / United States HL43201 / HL / NHLBI NIH HHS / United States N01-HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079-86 / HC / NHLBI NIH HHS / United States |