You are here
Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.
Tuesday,2021-07-20 20:02 America/Los_Angeles — ecterry
| Title | Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Hazzouri, AZeki Al, Vittinghoff, E, Hoang, T, Golden, SH, Fitzpatrick, AL, Zhang, A, Grasset, L, Yaffe, K |
| Journal | Alzheimers Dement |
| Date Published | 2021 May 13 |
| ISSN | 1552-5279 |
| Abstract | <p><b>INTRODUCTION: </b>To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women.</p><p><b>METHODS: </b>We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used.</p><p><b>RESULTS: </b>Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men.</p><p><b>CONCLUSIONS: </b>With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.</p> |
| DOI | 10.1002/alz.12367 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 33984188 |
| Grant List | / NH / NIH HHS / United States 1RF1AG054443 / AG / NIA NIH HHS / United States |
ePub date:
21/05