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Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults.

TitleSoluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults.
Publication TypeJournal Article
Year of Publication2006
AuthorsJenny, NS, Arnold, AM, Kuller, LH, Sharrett, AR, Fried, LP, Psaty, BM, Tracy, RP
JournalJ Thromb Haemost
Volume4
Issue1
Pagination107-13
Date Published2006 Jan
ISSN1538-7933
KeywordsAged, Aged, 80 and over, Angina Pectoris, Biomarkers, Cardiovascular Diseases, Female, Humans, Incidence, Intercellular Adhesion Molecule-1, Male, Mortality, Myocardial Infarction, Regression Analysis, Risk Factors, Sex Factors, Solubility, Stroke
Abstract<p><b>BACKGROUND: </b>Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression.</p><p><b>OBJECTIVES: </b>We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study.</p><p><b>METHODS: </b>Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up.</p><p><b>RESULTS: </b>sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events.</p><p><b>CONCLUSIONS: </b>While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.</p>
DOI10.1111/j.1538-7836.2005.01678.x
Alternate JournalJ Thromb Haemost
PubMed ID16409459
Grant ListN01 HC-15103 / HC / NHLBI NIH HHS / United States
N01-HC-35129 / HC / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States