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The association of alcohol consumption and incident heart failure: the Cardiovascular Health Study.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | The association of alcohol consumption and incident heart failure: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Bryson, CL, Mukamal, KJ, Mittleman, MA, Fried, LP, Hirsch, CH, Kitzman, DW, Siscovick, DS |
| Journal | J Am Coll Cardiol |
| Volume | 48 |
| Issue | 2 |
| Pagination | 305-11 |
| Date Published | 2006 Jul 18 |
| ISSN | 1558-3597 |
| Keywords | Aged, Alcohol Drinking, Chi-Square Distribution, Comorbidity, Female, Heart Failure, Humans, Life Style, Male, Multicenter Studies as Topic, Myocardial Infarction, Proportional Hazards Models, Risk Factors, Smoking |
| Abstract | <p><b>OBJECTIVES: </b>We investigated the association between alcohol consumption and incident congestive heart failure (CHF) both overall and after adjusting for incident myocardial infarction (MI).</p><p><b>BACKGROUND: </b>Moderate alcohol consumption has been associated with lower risk of CHF and MI.</p><p><b>METHODS: </b>The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects > or =65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption.</p><p><b>RESULTS: </b>There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week (hazard ratio [HR] 0.82, 95% confidence interval [CI] 0.67 to 1.00, p = 0.05) and 7 to 13 drinks per week (HR 0.66, 95% CI 0.47 to 0.91, p = 0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF (for 1 to 6 drinks per week, HR 0.84, 95% CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95% CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers (HR 1.51, p < 0.01), but those who quit during the study did not have a higher risk (HR 0.83, 95% CI 0.66 to 1.03).</p><p><b>CONCLUSIONS: </b>Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.</p> |
| DOI | 10.1016/j.jacc.2006.02.066 |
| Alternate Journal | J Am Coll Cardiol |
| PubMed ID | 16843180 |
| Grant List | N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States R37 AG018915 / AG / NIA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States |