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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
Tuesday,2021-07-20 14:39 America/Los_Angeles — ecterry
| Title | Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Harris, WS, Tintle, NL, Imamura, F, Qian, F, Korat, AVArdisson, Marklund, M, Djoussé, L, Bassett, JK, Carmichael, P-H, Chen, Y-Y, Hirakawa, Y, Küpers, LK, Laguzzi, F, Lankinen, M, Murphy, RA, Samieri, C, Senn, MK, Shi, P, Virtanen, JK, Brouwer, IA, Chien, K-L, Eiriksdottir, G, Forouhi, NG, Geleijnse, JM, Giles, GG, Gudnason, V, Helmer, C, Hodge, A, Jackson, R, Khaw, K-T, Laakso, M, Lai, H, Laurin, D, Leander, K, Lindsay, J, Micha, R, Mursu, J, Ninomiya, T, Post, W, Psaty, BM, Riserus, U, Robinson, JG, Shadyab, AH, Snetselaar, L, Sala-Vila, A, Sun, Y, Steffen, LM, Tsai, MY, Wareham, NJ, Wood, AC, H Y Wu, J, Hu, F, Sun, Q, Siscovick, DS, Lemaitre, RN, Mozaffarian, D |
| Corporate/Institutional Authors | Fatty Acids and Outcomes Research Consortium (FORCE) |
| Journal | Nat Commun |
| Volume | 12 |
| Issue | 1 |
| Pagination | 2329 |
| Date Published | 2021 04 22 |
| ISSN | 2041-1723 |
| Keywords | Aged, Aged, 80 and over, Cause of Death, Fatty Acids, Omega-3, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mortality, Premature, Prospective Studies, Protective Factors, Risk Factors |
| Abstract | <p>The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.</p> |
| DOI | 10.1038/s41467-021-22370-2 |
| Alternate Journal | Nat Commun |
| PubMed ID | 33888689 |
| PubMed Central ID | PMC8062567 |
ePub date:
21/04